Visualizing In Vitro Type I Collagen Fibrillogenesis by Transmission Electron Microscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7113-8_24
Abstract: Techniques and protocols for the in vitro formation of collagen type I fibrils and the extensive biochemical variation of the fibrillogenesis conditions are presented. In all cases, the incubation and fibrillogenesis product can be readily… read more here.
Keywords: collagen; microscopy; type; fibrillogenesis ... See more keywords
Oleanane triterpenoids from Akebiae Caulis exhibit inhibitory effects on Aβ42 induced fibrillogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-016-0885-7
Abstract: Previous phytochemical investigations of Akebiae Caulis resulted in the isolation of triterpenes, triterpene glycosides, phenylethanoid glycosides and megastigmane glycoside. Amyloid beta (Aβ), the main component of the senile plaques detected in Alzheimer’s disease, induces cell… read more here.
Keywords: inhibitory effects; oleanane triterpenoids; induced fibrillogenesis; effects induced ... See more keywords
Growth arrest specific protein 7 inhibits tau fibrillogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.041
Abstract: Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core… read more here.
Keywords: arrest specific; fibrillogenesis; growth arrest; specific protein ... See more keywords
Old dog, new tricks: Influenza a virus NS1 and in vitro fibrillogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.07.005
Abstract: The influenza NS1 protein is involved in suppression of the host immune response. Recently, there is growing evidence that prion-like protein aggregation plays an important role in cellular signaling and immune responses. In this work,… read more here.
Keywords: dog new; new tricks; tricks influenza; form ... See more keywords
Influence of the ionic liquid 1-butyl-3-methylimidazolium bromide on amyloid fibrillogenesis in lysozyme: Evidence from photophysical and imaging studies.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.10.152
Abstract: Many proteins can abnormally fold to form pathological amyloid deposits/aggregates that are responsible for various degenerative disorders called amyloidosis. Here we have examined the anti-amyloidogenic potency of an ionic liquid, 1-butyl-3-methylimidazolium bromide, using lysozyme as… read more here.
Keywords: ionic liquid; liquid; microscopy; butyl methylimidazolium ... See more keywords
Design of Gallic Acid-Glutamine Conjugate and Chemical Implications for Its Potency Against Alzheimer's Amyloid-β Fibrillogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00073
Abstract: Epigallocatechin-3-gallate (EGCG) has been widely recognized as a potent inhibitor of Alzheimer's amyloid-β (Aβ) fibrillogenesis. We found that gallic acid (GA) has superior inhibitory effects over EGCG at the same mass concentrations and assumed the… read more here.
Keywords: gallic acid; alzheimer amyloid; carboxyl; fibrillogenesis ... See more keywords
Multiple Cryptic Binding Sites are Necessary for Robust Fibronectin Assembly: An In Silico Study
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18328-4
Abstract: The mechanism of assembly of the extracellular matrix protein fibronectin (FN) into elastic, insoluble fibrils is still poorly understood. FN fibrillogenesis requires cell-generated forces, which expose cryptic FN-FN binding sites buried in FN Type III… read more here.
Keywords: multiple cryptic; cryptic binding; sites necessary; binding ... See more keywords
Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj8331
Abstract: Platelets interact with multiple adhesion proteins during thrombogenesis, yet little is known about their ability to assemble fibronectin matrix. In vitro three-dimensional superresolution microscopy complemented by biophysical and biochemical methods revealed fundamental insights into how… read more here.
Keywords: drive fibronectin; fibronectin fibrillogenesis; platelets drive; fibrillogenesis ... See more keywords