Imaging the dynamics and microstructure of fibrin clot polymerization in cardiac surgical patients using spectrally encoded confocal microscopy
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26217
Abstract: During cardiac surgery with cardiopulmonary bypass (CPB), altered hemostatic balance may disrupt fibrin assembly, predisposing patients to perioperative hemorrhage. We investigated the utility of a novel device termed spectrally‐encoded confocal microscopy (SECM) for assessing fibrin… read more here.
Keywords: clot; fibrin clot; microscopy; spectrally encoded ... See more keywords
Circumferential Suture Repair of Isolated Horizontal Meniscal Tears Augmented With Fibrin Clot
Sign Up to like & getrecommendations! Published in 2017 at "Arthroscopy Techniques"
DOI: 10.1016/j.eats.2017.06.031
Abstract: Traditionally, horizontal cleavage meniscus tears have been associated with osteoarthritis, indicative of the degenerative process. Recent treatment measures have focused on maintaining as much meniscal tissue as possible, despite the routine extension of these tears… read more here.
Keywords: circumferential suture; fibrin clot; horizontal meniscal; meniscal tears ... See more keywords
Repair of a Chronic Large Meniscal Defect With Implantation of Autogenous Meniscal Fragments Using a Tubular-Shaped Fibrin Clot
Sign Up to like & getrecommendations! Published in 2018 at "Arthroscopy Techniques"
DOI: 10.1016/j.eats.2017.09.002
Abstract: We present a technique to implant autogenous meniscal fragments using a fibrin clot to repair a large degenerative meniscal defect. A total of 25 mL of the patient's blood is agitated for 10 minutes using… read more here.
Keywords: clot; meniscal defect; fibrin clot; tubular shaped ... See more keywords
Fibrin clot properties among women with endometriosis and the impact of ovarian stimulation.
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2021.03.008
Abstract: RESEARCH QUESTION Is there a difference in fibrin clot phenotype in women with endometriosis before and after ovarian stimulation? DESIGN Prospective study including 73 infertile women in two age-matched groups: (i) with confirmed endometriosis (n = 29);… read more here.
Keywords: women endometriosis; fibrin clot; clot; ovarian stimulation ... See more keywords
The level of circulating fibroblast activation protein correlates with incorporation of alpha-2-antiplasmin into the fibrin clot.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.03.018
Abstract: INTRODUCTION Circulating fibroblast activation protein (cFAP) cleaves alpha-2-antiplasmin (α2AP) N-terminally, converting native Met-α2AP into Asn-α2AP. Previous studies in purified model systems showed that Asn-α2AP is faster incorporated into a fibrin clot by activated factor XIII… read more here.
Keywords: clot; 2ap incorporation; fibrin clot; level ... See more keywords
Intensive low-density lipoprotein cholesterol lowering improves fibrin clot properties: Association with lipoproteins and C-reactive protein.
Sign Up to like & getrecommendations! Published in 2022 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2022.106977
Abstract: OBJECTIVE Dense fibrin networks resistant to lysis characterize coronary artery disease (CAD) patients. We investigated whether a statin-induced decrease of low-density lipoprotein cholesterol (LDL-C) could improve fibrin clot phenotype in CAD patients. METHODS We recruited… read more here.
Keywords: ldl; lipoprotein; fibrin clot; cholesterol ... See more keywords
Differences in plasma fibrin clot composition in patients with thrombotic antiphospholipid syndrome compared with venous thromboembolism
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35034-x
Abstract: The prothrombotic fibrin clot phenotype has been reported in patients with thrombotic antiphospholipid syndrome (APS) and venous thromboembolism (VTE). Protein composition of plasma fibrin clots in APS has not been studied. We evaluated 23 patients… read more here.
Keywords: fibrin clot; patients thrombotic; composition; thrombotic antiphospholipid ... See more keywords
Reduced Plasma Magnesium Levels in Type-1 Diabetes Associate with Prothrombotic Changes in Fibrin Clotting and Fibrinolysis
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis and Haemostasis"
DOI: 10.1055/s-0039-3402808
Abstract: Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties… read more here.
Keywords: plasma magnesium; fibrin clot; magnesium; lysis ... See more keywords
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/s-0043-1768712
Abstract: BACKGROUND Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function. METHODS We evaluated 148 patients (age: 38 [32-50] years; 70% women) with genetically confirmed antithrombin… read more here.
Keywords: lower antithrombin; antithrombin deficiency; fibrin clot; deficiency ... See more keywords
Fibrin clot properties in cardiovascular disease: from basic mechanisms to clinical practice.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad017
Abstract: Fibrinogen conversion into insoluble fibrin and formation of a stable clot is the final step of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated lysis are the key fibrin measures, describing properties… read more here.
Keywords: clot; fibrin clot; cardiovascular disease; fibrin ... See more keywords
Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000005465
Abstract: OBJECTIVES: Disseminated fibrin-rich microthrombi have been reported in patients who died from COVID-19. Our objective is to determine whether the fibrin clot structure and function differ between critically ill patients with or without COVID-19 and… read more here.
Keywords: clot; fibrin clot; structure; critically ill ... See more keywords