The cortical blood–brain barrier in multiple sclerosis: a gateway to progression?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurology"
DOI: 10.1007/s00415-017-8727-1
Abstract: Despite the historical focus on white matter pathology, it is now increasingly recognised that cortical tissue injury is critical to disease outcome. Cortical pathology occurs from the earliest disease stages, predominates in progressive MS, and… read more here.
Keywords: bbb; matter; disease; pathology ... See more keywords
Blood-brain barrier leakage of blood proteins in idiopathic normal pressure hydrocephalus
Sign Up to like & getrecommendations! Published in 2019 at "Brain research"
DOI: 10.1016/j.brainres.2019.146547
Abstract: AIM Idiopathic normal pressure hydrocephalus (iNPH) is one subtype of dementia characterized by cerebrospinal fluid (CSF) disturbance, but with unknown cause. We recently reported that frontal cortex biopsies of iNPH patients disclosed degenerative alterations of… read more here.
Keywords: leakage blood; blood proteins; blood; fibrin ogen ... See more keywords
Fibrin opens the "gate" for leukocytes in the endothelium.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2017.12.006
Abstract: Migration of blood leukocytes through the layer of endothelial cells into extravascular sites of inflammation is essential for host defense and elimination of the consequences of tissue damage. The transendothelial migration of leukocytes has been… read more here.
Keywords: inflammation; leukocyte transmigration; fibrin; interaction ... See more keywords
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20210611
Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is characterized by unprecedented clinical pathologies. One of the most important pathologies, is hypercoagulation and microclots in the lungs… read more here.
Keywords: fibrin ogen; cov spike; spike protein; sars cov ... See more keywords
Interleukin‐12 and its procoagulant effect on erythrocytes, platelets and fibrin(ogen): the lesser known side of inflammation
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.15020
Abstract: Inflammation, with its associated inflammatory molecules, is integral to most chronic diseases, including the various cardiovascular diseases. Interleukin 12 (IL12) is one of the inflammatory cytokines that is upregulated during inflammation; however, we know very… read more here.
Keywords: interleukin procoagulant; microscopy; inflammation; effect ... See more keywords
Stem Bromelain Proteolytic Machinery: Study of the Effects of its Components on Fibrin (ogen) and Blood Coagulation.
Sign Up to like & getrecommendations! Published in 2020 at "Protein and peptide letters"
DOI: 10.2174/0929866527666200525163622
Abstract: BACKGROUND Antiplatelet, anticoagulant and fibrinolytic activities of stem bromelain (EC 3.4.22.4) are well described, but more studies are still required to clearly define its usefulness as an antithrombotic agent. Besides, although some effects of bromelain… read more here.
Keywords: stem bromelain; blood coagulation; activity; fibrin ogen ... See more keywords
Fibrin(ogen) Is Constitutively Expressed by Differentiated Intestinal Epithelial Cells and Mediates Wound Healing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.916187
Abstract: Fibrinogen is a large molecule synthesized in the liver and released in the blood. Circulating levels of fibrinogen are upregulated after bleeding or clotting events and support wound healing. In the context of an injury,… read more here.
Keywords: cell; fibrin ogen; wound healing; ogen ... See more keywords