Hemostatic Alterations in Patients With Cirrhosis: From Primary Hemostasis to Fibrinolysis
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31201
Abstract: In the setting of liver cirrhosis (LC), profound hemostatic changes occur, which affect primary hemostasis, coagulation, and fibrinolysis. They involve prohemorrhagic and prothrombotic alterations at each of these steps. Patients with cirrhosis exhibit multifactorial thrombocytopenia… read more here.
Keywords: alterations patients; hemostatic alterations; patients cirrhosis; primary hemostasis ... See more keywords
Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-01799-1
Abstract: Impaired endogenous fibrinolysis is an adverse prognostic biomarker in acute coronary syndrome (ACS). Abnormally dense in vitro fibrin thrombi have been demonstrated in ACS patients and related to hypofibrinolysis using cumbersome, laboratory-based methods. We aimed… read more here.
Keywords: point care; clot architecture; endogenous fibrinolysis; fibrinolysis ... See more keywords
Rationale and design of “Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)” study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-02014-5
Abstract: Impaired endogenous fibrinolysis is novel biomarker that can identify patients with ACS at increased cardiovascular risk. The addition of Very Low Dose Rivaroxaban (VLDR) to dual antiplatelet therapy has been shown to reduce cardiovascular events… read more here.
Keywords: status; vldr; low dose; addition ... See more keywords
The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hematology"
DOI: 10.1007/s12185-022-03308-w
Abstract: Coagulation and fibrinolytic mechanisms are enhanced in patients with coronavirus (COVID-19), but disturbances in the balance of both functions in COVID-19 patients remain unclear. We assessed global coagulation and fibrinolysis in plasma from 167 COVID-19… read more here.
Keywords: coagulation fibrinolytic; covid; moderate severe; coagulation ... See more keywords
Inherent Fibrin Fiber Tension Propels Mechanisms of Network Clearance During Fibrinolysis.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.02.025
Abstract: Proper wound healing necessitates both coagulation (the formation of a blood clot) and fibrinolysis (the dissolution of a blood clot). A thrombus resistant to clot dissolution can obstruct blood flow, leading to vascular pathologies. This… read more here.
Keywords: network; fiber; clearance; tension ... See more keywords
[Spontaneous coronary artery dissection in young male patient with STEMI: Unsuccessful fibrinolysis].
Sign Up to like & getrecommendations! Published in 2020 at "Annales de cardiologie et d'angeiologie"
DOI: 10.1016/j.ancard.2020.03.011
Abstract: Spontaneous coronary artery disease (SCAD) is a particular form of acute coronary syndrome affecting preferentially female patient with few or without traditional cardiovascular risk factors. Male patient is exceptionally concerned by SCAD. We report a… read more here.
Keywords: spontaneous coronary; artery; male patient; coronary artery ... See more keywords
What is the secondary patency of thrombosed bypasses of the lower limbs cleared by fibrinolysis in situ?
Sign Up to like & getrecommendations! Published in 2019 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2019.02.019
Abstract: OBJECTIVES In case of acute thrombosis, lower limbs bypasses can, in certain cases, be cleared by local intra-arterial fibrinolysis (LIF). The aim of this study was to evaluate the secondary patency of thrombosed bypasses after… read more here.
Keywords: patency; patency thrombosed; lower limbs; thrombosed bypasses ... See more keywords
Persistent Fibrinolysis Shutdown Is Associated with Increased Mortality in Severely Injured Trauma Patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Surgeons"
DOI: 10.1016/j.jamcollsurg.2016.12.018
Abstract: BACKGROUND Acute fibrinolysis shutdown is associated with early mortality after trauma; however, no previous studies have investigated the incidence of persistent fibrinolysis or its association with mortality. We tested the hypothesis that persistent fibrinolysis shutdown… read more here.
Keywords: shutdown associated; persistent fibrinolysis; mortality; fibrinolysis shutdown ... See more keywords
S62798, a potent TAFIa inhibitor, accelerates endogenous fibrinolysis in a murine model of pulmonary thromboembolism.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis research"
DOI: 10.1016/j.thromres.2021.06.007
Abstract: Enhancement of fibrinolysis constitutes a promising approach to treat thrombotic diseases. Venous thrombosis and thromboembolism risks are associated with increased plasma levels of TAFI (Thrombin Activatable Fibrinolysis Inhibitor) as well as its active form TAFIa.… read more here.
Keywords: inhibitor; thromboembolism; tafia inhibitor; s62798 ... See more keywords
Fibrinolysis in Living Donor Liver Transplantation Recipients Evaluated Using Thromboelastometry: Impact on Mortality.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2017.09.025
Abstract: BACKGROUND Inadequate hemostasis during living donor liver transplantation (LDLT) is mainly due to coagulopathy but may also include fibrinolysis. The purpose of this study was to determine the incidence of fibrinolysis and assess its relevance… read more here.
Keywords: anhepatic phase; liver transplantation; fibrinolysis; donor liver ... See more keywords
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01139
Abstract: Antifibrinolytic drugs provide important pharmacological interventions to reduce morbidity and mortality from excessive bleeding during surgery and after trauma. Current drugs used for inhibiting the dissolution of fibrin, the main structural component of blood clots,… read more here.
Keywords: highly potent; potent selective; inhibitor; trypsin inhibitor ... See more keywords