Persistent Fibrinolysis Shutdown Is Associated with Increased Mortality in Severely Injured Trauma Patients.
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DOI: 10.1016/j.jamcollsurg.2016.12.018
Abstract: BACKGROUND Acute fibrinolysis shutdown is associated with early mortality after trauma; however, no previous studies have investigated the incidence of persistent fibrinolysis or its association with mortality. We tested the hypothesis that persistent fibrinolysis shutdown… read more here.
Keywords: shutdown associated; persistent fibrinolysis; mortality; fibrinolysis shutdown ... See more keywords
Trending Fibrinolytic Dysregulation: Fibrinolysis Shutdown in the Days After Injury Is Associated With Poor Outcome in Severely Injured Children
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DOI: 10.1097/sla.0000000000002355
Abstract: Objective: To trend fibrinolysis after injury and determine the influence of traumatic brain injury (TBI) and massive transfusion on fibrinolysis status. Background: Admission fibrinolytic derangement is common in injured children and adults, and is associated… read more here.
Keywords: injured children; fibrinolysis shutdown; fibrinolysis; injury ... See more keywords
Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin
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DOI: 10.1097/ta.0000000000001685
Abstract: BACKGROUND A subset of trauma patients undergo fibrinolysis shutdown rather than pathologic hyperfibrinolysis, contributing to organ failure. The molecular basis for fibrinolysis shutdown in trauma is incompletely understood. Elastase released from primed/activated human neutrophils (HNE)… read more here.
Keywords: tpa; plasminogen; elastase; fibrinolysis shutdown ... See more keywords
Increased risk of fibrinolysis shutdown among severely injured trauma patients receiving tranexamic acid
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DOI: 10.1097/ta.0000000000001792
Abstract: BACKGROUND The association between tranexamic acid (TXA) and fibrinolysis shutdown is unknown. We hypothesize that TXA is associated with fibrinolysis shutdown in critically injured trauma patients. METHODS Two hundred eighteen critically injured adults admitted to… read more here.
Keywords: risk; tranexamic acid; trauma; fibrinolysis shutdown ... See more keywords