Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation
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DOI: 10.1002/advs.202415007
Abstract: Idiopathic pulmonary fibrosis (IPF) is characterized by excessive fibroblast recruitment and persistent extracellular matrix deposition at sites of tissue injury, leading to severe morbidity and mortality. However, the precise mechanisms by which fibroblasts contribute to… read more here.
Keywords: plexin; fibroblast activation; p61 sema3e; fibrosis ... See more keywords
A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000591
Abstract: Drugs targeting type 4 dipeptidyl peptidase (DPP‐4) are beneficial for glycemic control, whereas fibroblast activation protein alpha (FAP‐α) is a potential target for cancer therapies. Unlike other gliptins, linagliptin displays FAP inhibition. We compared biophysical… read more here.
Keywords: amino; amino acid; type dipeptidyl; dipeptidyl peptidase ... See more keywords
β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12203
Abstract: Abstract Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD), suggesting intimate communication between the two types of cells. However, the underlying mechanisms remain to be determined. Exosomes play a… read more here.
Keywords: cd44; catenin controlled; role; exosomes play ... See more keywords
[68Ga]FAPI PET/CT reveals increased pulmonary fibroblast activation protein expression in long COVID patients after ICU discharge
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-025-07376-y
Abstract: Post-acute sequelae of COVID-19 (PASC) has emerged as a major healthcare problem. A comprehensive mechanism of disease remains to be elucidated. In this study we aimed to explore pulmonary and muscle fibroblast activation protein (FAP)… read more here.
Keywords: covid patients; fibroblast activation; 68ga fapi; activation protein ... See more keywords
Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
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DOI: 10.1007/s00595-025-03024-y
Abstract: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP)… read more here.
Keywords: solitary fibrous; immunohistochemical staining; fibrous tumors; fibroblast activation ... See more keywords
Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein
Sign Up to like & getrecommendations! Published in 2017 at "Protoplasma"
DOI: 10.1007/s00709-017-1129-5
Abstract: The importance of the dipeptidyl peptidase 4 (DPP4) gene family in regulating critical biochemical pathways continues to emerge. The two most well-studied members of the family, DPP4 and fibroblast activation protein (FAP), have been investigated… read more here.
Keywords: disease biomarkers; disease; potential disease; activation protein ... See more keywords
Administration of Gas6 attenuates lung fibrosis via inhibition of the epithelial-mesenchymal transition and fibroblast activation
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DOI: 10.1007/s10565-024-09858-5
Abstract: The epithelial-mesenchymal transition (EMT) and fibroblast activation are major events in idiopathic pulmonary fibrosis pathogenesis. Here, we investigated whether growth arrest-specific protein 6 (Gas6) plays a protective role in lung fibrosis via suppression of the… read more here.
Keywords: fibrosis; fibroblast activation; administration; activation ... See more keywords
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2956-6
Abstract: The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts… read more here.
Keywords: endothelial mesenchymal; huvecs; cardiac fibroblasts; activation ... See more keywords
A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-α (FAPα)
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-021-01593-1
Abstract: Fibroblast activation protein-α (FAPα) is uniquely expressed in activated fibroblasts, including cancer-associated fibroblasts that populate tumor stroma and contribute to proliferation and immunosuppression. Radiolabeled FAPα inhibitors enable imaging of multiple human cancers, but time-dependent clearance… read more here.
Keywords: fap; rps 309; activation protein; ligand ... See more keywords
Myocardial fibroblast activation imaging in light chain cardiac amyloidosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nuclear Cardiology"
DOI: 10.1007/s12350-022-02963-0
Abstract: Light chains (AL) amyloidosis is a rare but lifethreatening disease. Cardiac involvement has the worst prognosis of any involved organ. Early identification of heart involvement may allow for prompt intervention and prevent irreversible myocardial remodeling.… read more here.
Keywords: light; cardiac amyloidosis; amyloidosis; fapi imaging ... See more keywords
Targeting Extracellular Matrix Glycation to Attenuate Fibroblast Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2022.01.040
Abstract: The extracellular matrix (ECM) of the tumor microenvironment undergoes constant remodeling that alters its biochemical and mechano-physical properties. Non-enzymatic glycation can induce the formation of advanced glycation end-products (AGEs), which may cause abnormal ECM turnover… read more here.
Keywords: age; extracellular matrix; glycation; matrix ... See more keywords