Human fibroblast‐derived extracellular vesicles promote hair growth in cultured human hair follicles
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14050
Abstract: Hair loss is a prevalent medical condition affecting both genders. In this study, we investigate the effects of a specific class of extracellular vesicles (EVs), namely human normal fibroblast‐derived EVs (hFB‐EVs), on human dermal papilla… read more here.
Keywords: extracellular vesicles; hfb evs; hair; fibroblast derived ... See more keywords
Fibroblast‐Derived Extracellular Vesicles Ameliorate the Skin Injury Microenvironment to Promote Wound Healing
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70063
Abstract: Fibroblasts are pivotal cellular components in cutaneous wound healing and are regarded as promising therapeutic candidates. However, their functional heterogeneity within tissue microenvironments significantly limits their clinical application. In contrast, whether fibroblast‐derived extracellular vesicles (EVs)… read more here.
Keywords: extracellular vesicles; hdf evs; fibroblast; derived extracellular ... See more keywords
Single‐Cell Analysis Reveals Fibroblast‐Derived Migrasomes as CXCL12 Carriers Promoting Skin Wound Repair
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70112
Abstract: ABSTRACT Migrasomes are newly discovered organelles with demonstrated functions in organ morphogenesis and angiogenesis. However, the effect of migrasomes in tissue repair remains unreported. Our super‐resolution confocal microscopy and focused ion beam scanning electron microscopy… read more here.
Keywords: single cell; derived migrasomes; repair; wound healing ... See more keywords
Identification of a fibroblast-derived gene signature reveals prognostic and therapeutic insights in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-025-01801-0
Abstract: Fibroblasts play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). This study aimed to develop a prognostic model based on fibroblast-specific gene signatures and identify key genes that may serve as therapeutic… read more here.
Keywords: identification fibroblast; derived gene; signature; fibroblast derived ... See more keywords
Abstract Wed057: Impact of Fibroblast-Derived Hyaluronan on Acute Ventricular Remodeling
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.wed057
Abstract: Background: Following myocardial infarction (MI), the extracellular matrix (ECM) component hyaluronan (HA) accumulates. Our recent work shows that Has2 expression in fibroblasts drives accumulation of HA. The role of HA following MI is largely unknown.… read more here.
Keywords: per group; acute ventricular; group; fibroblast derived ... See more keywords
Atrial fibroblast–derived macrophage migration inhibitory factor promotes atrial macrophage accumulation in postoperative atrial fibrillation
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.190756
Abstract: New study: Blocking MIF protein prevents irregular heartbeats after surgery by reducing harmful immune cell buildup in the atria. read more here.
Keywords: atrial fibroblast; migration inhibitory; derived macrophage; fibroblast derived ... See more keywords
Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27050
Abstract: Gremlin1 (GREM1) is a secreted glycoprotein member of the differential screening-selected gene in aberrant neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists, which binds to BMPs preventing their receptor engagement. Previous studies have identified… read more here.
Keywords: crypt; fibroblast derived; expression; derived gremlin1 ... See more keywords
Bioactive Hydrogel Supplemented with Stromal Cell-Derived Extracellular Vesicles Enhance Wound Healing
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17020162
Abstract: Background/Objectives: Skin regeneration is a rapidly advancing field with significant implications for regenerative medicine, particularly in treating wounds and burns. This study explores the potential of hydrogels functionalized with fibroblast-derived extracellular vesicles (EVs) to enhance… read more here.
Keywords: extracellular vesicles; derived extracellular; wound healing; cell ... See more keywords
Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.114417
Abstract: Rationale: The transition of fibroblasts into activated myofibroblasts is a pivotal driver of collagen deposition and adverse cardiac remodeling. Insulin-like growth factor-binding protein 6 (IGFBP6), a critical modulator of cellular growth and metabolism via its… read more here.
Keywords: igfbp6; derived igfbp6; cardiac remodeling; fibroblast ... See more keywords
Fibroblast-derived NEU1 as a therapeutic target for improving cortical bone integrity and fracture healing.
Sign Up to like & getrecommendations! Published in 2026 at "Theranostics"
DOI: 10.7150/thno.119200
Abstract: Rationale: Bone fractures, particularly in aging populations, present significant clinical challenges due to prolonged healing times and increased risk of complications. A deeper understanding of the molecular mechanisms regulating bone metabolism and repair is essential… read more here.
Keywords: sialic acid; fracture healing; cell; fibroblast derived ... See more keywords
Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway: Erratum
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.69175
Abstract: [This corrects the article DOI: 10.7150/thno.22182.]. read more here.
Keywords: cancer; fibroblast derived; associated fibroblast; derived promotes ... See more keywords