Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301353
Abstract: Collagen alignment is one of the key microarchitectural signatures of many pathological conditions, including scarring and fibrosis. Investigating how collagen alignment modulates cellular functions will pave the way for understanding tissue scarring and regeneration and… read more here.
Keywords: fibroblast differentiation; collagen; alignment; via cell ... See more keywords
Baicalein represses TGF‐&bgr;1‐induced fibroblast differentiation through the inhibition of miR‐21
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.09.007
Abstract: ABSTRACT Fibroblast‐to‐myofibroblast differentiation is a highly important pathological characteristic of pulmonary fibrosis. In this study, we aimed to investigate the effects and mechanisms of baicalein on the differentiation of human lung fibroblasts. Baicalein reduced the… read more here.
Keywords: tgf bgr; mir; fibroblast differentiation; baicalein ... See more keywords
Controlling Multiscale Network Structure of Fibers to Stimulate Wound Matrix Rebuilding by Fibroblast Differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b06439
Abstract: Extracellular matrix (ECM) play a double-edged sword role for controlling the differentiation of fibroblast toward contractile myofibroblast in the wound healing process. However, the exact structure-function relationship between ECM morphology and fibroblast behaviors still remains… read more here.
Keywords: wound healing; matrix; fiber; fibroblast differentiation ... See more keywords
Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08741-1
Abstract: Keloids are dermal fibroproliferative skin disorders caused by abnormal wound healing, resulting in impaired skin function and aesthetic defects. Abnormal fibroblast proliferation and excessive collagen deposition are involved in keloid formation. This study investigated the… read more here.
Keywords: differentiation; classification; single cell; fibroblast differentiation ... See more keywords
Microvesicles-delivering Smad7 have advantages over microvesicles in suppressing fibroblast differentiation in a model of Peyronie’s disease
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DOI: 10.1186/s12896-024-00866-1
Abstract: This study compared the differences of microvesicles (MVs) and microvesicles-delivering Smad7 (Smad7-MVs) on macrophage M1 polarization and fibroblast differentiation in a model of Peyronie’s disease (PD). Overexpression of Smad7 in rat BMSCs was obtained by… read more here.
Keywords: differentiation; mvs treatment; fibroblast differentiation; smad7 mvs ... See more keywords
HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia
Sign Up to like & getrecommendations! Published in 2021 at "Respiratory Research"
DOI: 10.1186/s12931-021-01916-4
Abstract: Background Pulmonary fibrosis is thought to be driven by recurrent alveolar epithelial injury which leads to the differentiation of fibroblasts into α-smooth muscle actin (α-SMA)-expressing myofibroblasts and subsequent deposition of extracellular matrix (ECM). Transforming growth… read more here.
Keywords: differentiation; tgf; metabolic reprogramming; fibroblast differentiation ... See more keywords