Fibroblast Growth Factor 2‐Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201902372
Abstract: Abstract Extracellular vesicles (EVs) are endogenous membrane‐derived vesicles that shuttle bioactive molecules between glia and neurons, thereby promoting neuronal survival and plasticity in the central nervous system (CNS) and contributing to neurodegenerative conditions. Although EVs… read more here.
Keywords: vamp3 cellubrevin; hippocampal neurons; fibroblast growth; growth factor ... See more keywords
Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus
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DOI: 10.1002/advs.202004168
Abstract: Abstract Fibroblast growth factor 21 (FGF21) is a liver‐derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic homeostasis reduce FGF21. Whether abnormalities in FGF21… read more here.
Keywords: growth factor; fgf21; factor; fibroblast growth ... See more keywords
TAS‐120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure
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DOI: 10.1002/cmdc.201800719
Abstract: 1‐[(3S)‐3‐[4‐Amino‐3‐[2‐(3,5‐dimethoxyphenyl)ethynyl]‐1H‐pyrazolo[3,4‐d]pyrimidin‐1‐yl]‐1‐pyrrolidinyl]‐2‐propen‐1‐one (TAS‐120) is an irreversible inhibitor of the fibroblast growth factor receptor (FGFR) family, and is currently under phase I/II clinical trials in patients with confirmed advanced metastatic solid tumours harbouring FGFR aberrations. This inhibitor specifically… read more here.
Keywords: tas 120; fibroblast growth; growth factor; reactivity ... See more keywords
Changes in early optical coherence tomography angiography among children and adolescents with type 1 diabetes: Relation to fibroblast growth factor 21
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3598
Abstract: Current diagnostic and treatment modalities target late stages of diabetic retinopathy (DR) when retinopathy has already been established. Novel and more sensitive strategies are needed. Optical coherence tomography angiography (OCTA) permits non‐invasive visualisation of retinal… read more here.
Keywords: optical coherence; among children; growth factor; tomography angiography ... See more keywords
Lack of discreet colocalization of epithelial apoptosis to the atretic precursor in the colon of the Fibroblast growth factor receptor 2IIIb mouse and staining consistent with cellular movement suggest a revised model of atresia formation
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.164
Abstract: Colonic atresias in the Fibroblast growth factor receptor 2IIIb (Fgfr2IIIb) mouse model have been attributed to increased epithelial apoptosis and decreased epithelial proliferation at embryonic day (E) 10.5. We therefore hypothesized that these processes would… read more here.
Keywords: fibroblast growth; colon; growth factor; epithelial apoptosis ... See more keywords
Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24468
Abstract: Fibroblast growth factors (FGFs) constitute a large family of polypeptides that are involved in many biological processes, ranging from prenatal cell‐fate specification and organogenesis to hormonal and metabolic regulation in postnatal life. During embryonic development,… read more here.
Keywords: pathological roles; fibroblast growth; growth factors; therapeutic pathological ... See more keywords
Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18)
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Dynamics"
DOI: 10.1002/dvdy.85
Abstract: Fibroblast growth factor 18 (FGF18) functions in the development of several tissues, including the lung, limb bud, palate, skeleton, central nervous system, and hair follicle. Mice containing a germline knockout of Fgf18 (Fgf18 −/−) die… read more here.
Keywords: growth factor; factor fgf18; fibroblast growth; fgf18 ... See more keywords
Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking Through a Door Half‐Opened
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DOI: 10.1002/hep.30069
Abstract: Cholangiocarcinoma (CCA), the most common biliary tract malignancy, represents a heterogeneous group of epithelial cancers arising from varying locations within the biliary tree. The anatomical subtypes of CCA are intrahepatic CCA (iCCA), which arises in… read more here.
Keywords: fibroblast growth; cholangiocarcinoma; cca; growth factor ... See more keywords
Fibroblast Growth Factor 19–Mediated Up‐regulation of SYR‐Related High‐Mobility Group Box 18 Promotes Hepatocellular Carcinoma Metastasis by Transactivating Fibroblast Growth Factor Receptor 4 and Fms‐Related Tyrosine Kinase 4
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.30951
Abstract: The poor prognosis of patients with hepatocellular carcinoma (HCC) is mainly attributed to its high rate of metastasis and recurrence. However, the molecular mechanisms underlying HCC metastasis need to be elucidated. The SRY‐related high‐mobility group… read more here.
Keywords: growth factor; fibroblast growth; group; metastasis ... See more keywords
Activating Adenosine Monophosphate–Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice
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DOI: 10.1002/hep.31568
Abstract: Fibroblast growth factor (FGF) 1 demonstrated protection against nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic and obese mice by an uncertain mechanism. This study investigated the therapeutic activity and mechanism of a nonmitogenic… read more here.
Keywords: fatty liver; protection nonalcoholic; fibroblast growth; growth factor ... See more keywords
Hepatic Fibroblast Growth Factor 21 Is Involved in Mediating Functions of Liraglutide in Mice With Dietary Challenge
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31856
Abstract: Several studies have shown that expression of hepatic fibroblast growth factor 21 (FGF21) can be stimulated by glucagon‐like peptide 1 (GLP‐1)–based diabetes drugs. As GLP‐1 receptor (GLP‐1R) is unlikely to be expressed in hepatocytes, we… read more here.
Keywords: growth factor; fibroblast growth; hepatic fibroblast;