Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28098
Abstract: Fibroblast‐like synoviocytes (FLSs) play an essential role in the chronic inflammatory process of rheumatoid arthritis (RA). Carvacrol is a natural monoterpenic phenol that retains significant anti‐inflammatory activity. However, the effect of carvacrol on inflammatory response… read more here.
Keywords: suppresses inflammatory; fibroblast like; like synoviocytes; carvacrol suppresses ... See more keywords
Forkhead box o3a suppresses lipopolysaccharide‐stimulated proliferation and inflammation in fibroblast‐like synoviocytes through regulating tripartite motif‐containing protein 3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28615
Abstract: Fibroblast‐like synoviocytes (FLS), synovial tissue‐specific cells, are key effector cells during the pathogenesis of rheumatoid arthritis (RA). Our previous study has shown that tripartite motif‐containing protein 3 (TRIM3) overexpression inhibits the proliferation and cytokine secretion… read more here.
Keywords: foxo3a trim3; fibroblast like; like synoviocytes; foxo3a ... See more keywords
Effect of Fibroblast-Like Cells of Mesenchymal Origin of Cytotoxic Activity of Lymphocytes against NK-Sensitive Target Cells
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3658-5
Abstract: We studied immunosuppressive properties of skin fibroblasts and mesenchymal stromal cells against NK cells. In vitro experiments showed that mesenchymal stromal cells isolated from human umbilical cord and human skin fibroblasts can considerably attenuate cytotoxic… read more here.
Keywords: fibroblast like; cells mesenchymal; like cells; activity ... See more keywords
Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF-κB/P65 Pathway in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0809-4
Abstract: Src-associated substrate during mitosis of 68 KDa (Sam68), also known as KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), is the prototypic member of the signal transduction activator of RNA (STAR) family of RNA-binding… read more here.
Keywords: fibroblast like; like synoviocytes; proliferation; migration ... See more keywords
miR-410-3p Suppresses Cytokine Release from Fibroblast-Like Synoviocytes by Regulating NF-κB Signaling in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0896-2
Abstract: AbstractmiR-410-3p acts as an oncogene or a tumor suppressor in some malignancies. However, its role in rheumatoid arthritis (RA) is unknown. The study was conducted to investigate the effect of miR-410-3p on the pathogenesis of… read more here.
Keywords: 410 suppresses; fibroblast like; regulating signaling; like synoviocytes ... See more keywords
Long Non-coding RNA THRIL Mediates Cell Growth and Inflammatory Response of Fibroblast-Like Synoviocytes by Activating PI3K/AKT Signals in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01189-x
Abstract: The present study explored the possible functions and the underlying mechanism of tumor necrosis factor-α (TNF-α) and heterogeneous nuclear ribonucleoprotein L (hnRNPL)–related immunoregulatory lncRNA plasmacytoma variant translocation 1 (THRIL) in rheumatoid arthritis (RA). Serum samples… read more here.
Keywords: fibroblast like; pi3k akt; rheumatoid arthritis; thril ... See more keywords
The Fibroblast-Like Synoviocyte Derived Exosomal Long Non-coding RNA H19 Alleviates Osteoarthritis Progression Through the miR-106b-5p/TIMP2 Axis
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01227-8
Abstract: Osteoarthritis (OA) is a common degenerative joint disease that affects people worldwide. The interaction between fibroblast-like synoviocytes (FLSs) and chondrocytes may play a vital role in OA disease pathology. However, the underlying mechanisms by which… read more here.
Keywords: fibroblast like; timp2 axis; 106b timp2; mir 106b ... See more keywords
Low-intensity pulsed ultrasound inhibits IL-1β-induced inflammation of fibroblast-like synoviosytes via NF-κB pathway
Sign Up to like & getrecommendations! Published in 2020 at "Applied Acoustics"
DOI: 10.1016/j.apacoust.2020.107384
Abstract: Abstract Osteoarthritis (OA) is a degenerative joint disease, which is usually accompanied by inflammation. The aim of this study was to evaluate the anti-inflammatory effect of Low-intensity pulsed ultrasound (LIPUS) on OA. Fibroblast-Like Synoviocyte (FLS)… read more here.
Keywords: pulsed ultrasound; fibroblast like; inflammation; intensity ... See more keywords
A20 inhibits the release of inflammatory cytokines by suppressing the activation of the nuclear factor-kappa B pathway in osteoarthritic fibroblast-like synoviocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.030
Abstract: A growing number of studies suggest that synovitis plays an important role in the pathogenesis and progression of osteoarthritis (OA). As a negative mediator of the nuclear factor-kappa B (NF-κB) signaling pathway, the zinc finger… read more here.
Keywords: fibroblast like; like synoviocytes; inflammatory cytokines; factor kappa ... See more keywords
Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2022.119134
Abstract: Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents. Despite the increasing amount… read more here.
Keywords: fibroblast like; like synoviocytes; effect; sulfated polysaccharides ... See more keywords
Potential therapeutic effect of curcumin loaded hyalurosomes against inflammatory and oxidative processes involved in the pathogenesis of rheumatoid arthritis: The use of fibroblast‐like synovial cells cultured in synovial fluid
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2019.01.012
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT In the present work curcumin loaded hyalurosomes were proposed as innovative systems for the treatment of rheumatoid arthritis. Vesicles were prepared using a one‐step and environmentally friendly method.… read more here.
Keywords: curcumin loaded; fibroblast like; loaded hyalurosomes; rheumatoid arthritis ... See more keywords