ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2046448
Abstract: Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration are major clinical manifestations of this disease; hence, blocking these processes is a practical… read more here.
Keywords: pulmonary fibrosis; myofibroblast differentiation; linc00941; elavl1 ... See more keywords
Fibroblast to myofibroblast transition is enhanced by increased cell density
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-08-0536
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic disease of the lung caused by a rampant inflammatory response that results in the deposition of excessive extracellular matrix (ECM). IPF patient lungs also develop fibroblastic foci that… read more here.
Keywords: increased cell; myofibroblast transition; density; cell density ... See more keywords
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
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DOI: 10.1098/rsob.210356
Abstract: Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause… read more here.
Keywords: myofibroblast differentiation; extracellular matrix; fibroblast myofibroblast; tissue ... See more keywords
Deficient Follistatin‐like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast‐to‐Myofibroblast Transition
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DOI: 10.1165/rcmb.2017-0025oc
Abstract: &NA; Bronchial epithelial cells (BECs) from healthy children inhibit human lung fibroblast (HLF) expression of collagen and fibroblast‐to‐myofibroblast transition (FMT), whereas asthmatic BECs do so less effectively, suggesting that diminished epithelial‐derived regulatory factors contribute to… read more here.
Keywords: secretion; asthmatic becs; expression; becs ... See more keywords
MYH9 Inhibition Suppresses TGF-β1-Stimulated Lung Fibroblast-to-Myofibroblast Differentiation
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DOI: 10.3389/fphar.2020.573524
Abstract: Previous cDNA microarray results showed that MYH9 gene expression levels are increased in TGF-β1-stimulated lung fibroblast. Recently, our proteomic results revealed that the expression levels of MYH9 protein are notably upregulated in lung tissues of… read more here.
Keywords: lung; lung fibroblast; differentiation; tgf stimulated ... See more keywords
Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214088
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal interstitial lung disease with unknown etiology. Despite substantial progress in understanding the pathogenesis of pulmonary fibrosis and drug development, there is still no cure for… read more here.
Keywords: myofibroblast differentiation; fibrosis mice; bleomycin induced; fibroblast myofibroblast ... See more keywords