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   Articles with "fibroblast phenotype" as a keyword



Human Adventitial Fibroblast Phenotype Depends on the Progression of Changes in Substrate Stiffness.

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recommendations! Published in 2020 at "Advanced healthcare materials"

DOI: 10.1002/adhm.201901593

Abstract: Adventitial fibroblasts (AFs) are major contributors to vascular remodeling and maladaptive cascades associated with arterial disease, where AFs both contribute to and respond to alterations in their surrounding matrix. The relationships between matrix modulus and… read more here.

Keywords: depends progression; progression changes; adventitial fibroblast; phenotype depends ... See more keywords

A miRNA-145/TGF-&bgr;1 negative feedback loop regulates the cancer-associated fibroblast phenotype

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recommendations! Published in 2018 at "Carcinogenesis"

DOI: 10.1093/carcin/bgy032

Abstract: The dissemination of cancer cells to local and distant sites depends on a complex and poorly understood interplay between malignant cells and the cellular and non-cellular components surrounding them, collectively termed the tumour microenvironment. One… read more here.

Keywords: phenotype; mir 145; caf; cancer associated ... See more keywords

Targeting fibroblast phenotype switching in cardiac remodelling as a promising antifibrotic strategy.

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recommendations! Published in 2024 at "European heart journal"

DOI: 10.1093/eurheartj/ehae722

Abstract: Myocardial fibrosis, a common feature of heart disease, remains an unsolved clinical challenge. Fibrosis resolution requires activation of cardiac fibroblasts exhibiting context-dependent beneficial and detrimental dichotomy. Here, we explored the hypothesis of fibroblast reversible transition… read more here.

Keywords: cardiac remodelling; phenotype switching; fibrosis; fibroblast phenotype ... See more keywords

Single-Cell Transcriptome Integration Analysis Reveals the Correlation Between Mesenchymal Stromal Cells and Fibroblasts

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.798331

Abstract: Background: Mesenchymal stromal cells (MSCs) and fibroblasts show similar morphology, surface marker expression, and proliferation, differentiation, and immunomodulatory capacities. These similarities not only blur their cell identities but also limit their application. Methods: We performed… read more here.

Keywords: cell; cell transcriptome; single cell; cell subsets ... See more keywords