Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis
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DOI: 10.1159/000495217
Abstract: Background/Aims: Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as… read more here.
Keywords: fibroblast specific; specific protein; soluble cd163; levels urinary ... See more keywords
Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts
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DOI: 10.1161/circulationaha.120.051583
Abstract: Supplemental Digital Content is available in the text. Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may increase fibrosis within… read more here.
Keywords: sinoatrial node; human sinoatrial; fibroblast specific; failing hearts ... See more keywords
Fibroblast-specific IKK-β deficiency ameliorates angiotensin II–induced adverse cardiac remodeling in mice
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DOI: 10.1172/jci.insight.150161
Abstract: Cardiac inflammation and fibrosis contribute significantly to hypertension-related adverse cardiac remodeling. IκB kinase β (IKK-β), a central coordinator of inflammation through activation of NF-κB, has been demonstrated as a key molecular link between inflammation and… read more here.
Keywords: adverse cardiac; fibroblast; specific ikk; cardiac remodeling ... See more keywords
Fibroblast-Specific β-Catenin Signaling Dictates the Outcome of AKI.
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DOI: 10.1681/asn.2017080903
Abstract: AKI is a devastating condition with high morbidity and mortality. The pathologic features of AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether fibroblasts in the renal interstitium have a role in the… read more here.
Keywords: gli1 cat; catenin; specific catenin; fibroblast specific ... See more keywords
Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
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DOI: 10.3389/fcvm.2021.664626
Abstract: Cardiac remodeling consisted of ventricular hypertrophy and interstitial fibrosis is the pathological process of many heart diseases. Fibroblasts as one of the major cells in the myocardium regulate the balance of the generation and degeneration… read more here.
Keywords: induced cardiac; cardiac fibroblast; cardiac remodeling; fibroblast specific ... See more keywords
Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-β signaling
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DOI: 10.7150/thno.77043
Abstract: Rationale: Extracellular matrix (ECM) remodeling, a key pathological feature in diabetic cardiomyopathy (DCM), is triggered by oxidative stress, inflammation, and various metabolic disorders in the heart. Cardiac fibroblasts (CFs) are the primary source of ECM… read more here.
Keywords: notch tgf; rnd3; fibroblast specific; tgf signaling ... See more keywords