Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts
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DOI: 10.1080/13880209.2022.2101672
Abstract: Abstract Context (-)-Epicatechin (EPI) is a crucial substance involved in the protective effects of flavanol-rich foods. Previous studies have indicated EPI has a cardioprotective effect, but the molecular mechanisms in inhibition of cardiac fibrosis are… read more here.
Keywords: cardiac fibrosis; cardiac fibroblasts; tac; sirt1 ... See more keywords
Sodium Tanshinone IIA Sulfonate Prevents Angiotensin II-Induced Differentiation of Human Atrial Fibroblasts into Myofibroblasts
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DOI: 10.1155/2018/6712585
Abstract: Differentiation of atrial fibroblasts into myofibroblasts plays a critical role in atrial fibrosis. Sodium tanshinone IIA sulfonate (DS-201), a water-soluble derivative of tanshinone IIA, has been shown to have potent antifibrotic properties. However, the protective… read more here.
Keywords: induced differentiation; atrial fibroblasts; tanshinone iia; fibroblasts myofibroblasts ... See more keywords
Therapeutic Potential of Exosomes in Pulmonary Fibrosis
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DOI: 10.3389/fphar.2020.590972
Abstract: Pulmonary fibrosis is closely associated with the recruitment of fibroblasts from capillary vessels with damaged endothelial cells, the epithelial mesenchymal transition (EMT) of type II alveolar epithelial cells, and the transformation of fibroblasts to myofibroblasts.… read more here.
Keywords: fibrosis; transformation fibroblasts; potential exosomes; pulmonary fibrosis ... See more keywords
Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways
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DOI: 10.3389/fphar.2022.901000
Abstract: Background: Vincristine (VCR) is used in the clinic as an anti-tumor drug. VCR can cause pulmonary fibrosis (PF), leading to respiratory failure. The transformation of fibroblasts into myofibroblasts may play a key role in PF.… read more here.
Keywords: vcr; erk1; expression; mapk ... See more keywords