Significance of MR/OPN/HMGB1 axis in NAFLD-associated hepatic fibrogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118619
Abstract: AIMS The activation of hepatic stellate cells (HSCs) plays a central role in liver fibrosis, however non-alcoholic fatty liver disease (NAFLD) associated liver fibrogenesis have been poorly understood. We aimed to determine the significance of… read more here.
Keywords: hmgb1; fibrogenesis; nafld associated; opn hmgb1 ... See more keywords
Folate Decoration Supports the Targeting of Camptothecin Micelles against Activated Hepatic Stellate Cells and the Suppression of Fibrogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c16616
Abstract: As the central cellular player in fibrogenesis, activated hepatic stellate cells (aHSCs) are the major target of antifibrotic nanomedicines. Based on our finding that activated HSCs increase the expression of folate receptor alpha (FRα), we… read more here.
Keywords: stellate cells; fibrogenesis; decoration; hepatic stellate ... See more keywords
Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06231
Abstract: Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde containing amino acid allysine (LysAld). Here, we describe the… read more here.
Keywords: liver fibrogenesis; fibrogenesis; imaging liver; manganese based ... See more keywords
TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00671-1
Abstract: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix. Moreover, TIMP-1 displays anti-apoptotic properties,… read more here.
Keywords: fibrogenesis carcinogenesis; fibrogenesis; hepatic fibrogenesis; timp ... See more keywords
A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18555-9
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts. We aimed to develop a human… read more here.
Keywords: fibrosis; fibrogenesis; idiopathic pulmonary; model ... See more keywords
An Evaluation of the Collagen Fragments Related to Fibrogenesis and Fibrolysis in Nonalcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30457-y
Abstract: Fibrosis, resulted from the imbalance of fibrogenesis and fibrolysis, is a key readout of disease progression in nonalcoholic steatohepatitis (NASH) and reflects mortality risk. Non-invasive biomarkers capable of diagnosing fibrosis stages and monitoring fibrosis changes… read more here.
Keywords: collagen; fibrosis; nonalcoholic steatohepatitis; fibrogenesis ... See more keywords
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq6297
Abstract: Liver fibrosis plays a critical role in the evolution of most chronic liver diseases and is characterized by a buildup of extracellular matrix, which can progress to cirrhosis, hepatocellular carcinoma, liver failure, or death. Now,… read more here.
Keywords: liver; fibrogenesis; detection; treatment ... See more keywords
An experimental model of the epithelial to mesenchymal transition and pro-fibrogenesis in urothelial cells related to bladder pain syndrome/interstitial cystitis.
Sign Up to like & getrecommendations! Published in 2021 at "Translational andrology and urology"
DOI: 10.21037/tau-21-392
Abstract: Background Suitable in vitro models are needed to investigate urothelial epithelial to mesenchymal transition (EMT) and pro-fibrogenesis phenotype in bladder pain syndrome/interstitial cystitis (BPS/IC). This study is to establish a novel experimental BPS/IC cell model… read more here.
Keywords: pro fibrogenesis; urothelial cells; fibrogenesis phenotype; fibrogenesis ... See more keywords
MiR-30b-5p and miR-22-3p restrain the fibrogenesis of post-myocardial infarction in mice via targeting PTAFR.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202004_20869
Abstract: OBJECTIVE Cardiac fibrosis of post-myocardial infarction (MI) is a precipitating factor of diverse cardiac diseases. MicroRNAs (miRNAs) have been reported to be implicated in the progression of cardiac fibrosis, but the functions and mechanisms of… read more here.
Keywords: mir 30b; fibrogenesis; mir; post myocardial ... See more keywords
Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00150
Abstract: Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to… read more here.
Keywords: stellate cell; fibrogenesis; hepatic stellate; activation ... See more keywords
Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12050471
Abstract: Osteoprotegerin (OPG) serum levels are associated with liver fibrogenesis and have been proposed as a biomarker for diagnosis. However, the source and role of OPG in liver fibrosis are unknown, as is the question of… read more here.
Keywords: fibrogenesis; function human; fibrosis; murine liver ... See more keywords