Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice
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DOI: 10.3389/fcell.2021.812748
Abstract: Fibrosis is an evolutionarily conserved pathophysiological process serving bifurcated purposes. On the one hand, fibrosis is essential for wound healing and contributes to the preservation of organ function. On the other hand, aberrant fibrogenic response… read more here.
Keywords: pro fibrogenic; mkl1; resident fibroblast; mice ... See more keywords
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase
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DOI: 10.3748/wjg.v24.i7.819
Abstract: AIM To investigate the effect of metformin on activated hepatic stellate cells (HSCs) and the possible signaling pathways involved. METHODS A fibrotic mouse model was generated by intraperitoneal injection of carbon tetrachloride (CCl4) and subsequent… read more here.
Keywords: hscs; kinase; metformin; contraction ... See more keywords