Fibrolamellar carcinoma: Challenging the challenge.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.06.035
Abstract: Fibrolamellar carcinoma (FLC) is a rare and poorly understood malignancy, which seems to be more prevalent in young patients compared with conventional hepatocellular carcinoma (HCC). Performing prospective clinical trials recruiting patients diagnosed with FLC has… read more here.
Keywords: challenging challenge; carcinoma; ifn; treatment ... See more keywords
Fibrolamellar Carcinoma: What Is New and Why It Matters.
Sign Up to like & getrecommendations! Published in 2018 at "Surgical pathology clinics"
DOI: 10.1016/j.path.2018.02.006
Abstract: Fibrolamellar carcinoma is distinctive at clinical and histologic levels. A novel DNAJB1-PRKACA fusion gene characterizes almost all cases, distinguishes it from other hepatocellular neoplasms, and drives the pathogenesis of this unique tumor. A subset of… read more here.
Keywords: carcinoma new; fibrolamellar carcinoma; new matters; pathology ... See more keywords
Environmental exposures as a risk factor for fibrolamellar carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2017.7
Abstract: Fibrolamellar carcinoma was first described in 1956. Subsequent large studies failed to identify cases before 1939 (the start of the World War II). This finding, combined with the presence of aryl hydrocarbon receptors on the… read more here.
Keywords: exposures risk; carcinoma; world war; environmental exposures ... See more keywords
Fibrolamellar carcinoma transcriptomic-based treatment prediction: complete response after nivolumab and ipilimumab
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005620
Abstract: Fibrolamellar carcinoma (FLC) is a rare cancer of the liver that most commonly affects children and young adults. There is no clear standard of care for the disease, whose response to treatment seems to be… read more here.
Keywords: fibrolamellar carcinoma; nivolumab; ipilimumab; treatment ... See more keywords
Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154743
Abstract: Fibrolamellar carcinoma (FLC) is an aggressive liver cancer primarily afflicting adolescents and young adults. Most patients with FLC harbor a heterozygous deletion on chromosome 19 that leads to the oncogenic gene fusion, DNAJB1-PRKACA. There are… read more here.
Keywords: mir 10b; multiomic analysis; fibrolamellar carcinoma; flc ... See more keywords
External beam and stereotactic radiation in the treatment of fibrolamellar carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2022.40.16_suppl.e16137
Abstract: e16137 Background: Fibrolamellar Carcinoma (FLC) is an extremely rare (< 50 cases/year US), distinct type of primary liver cancer, unrelated to hepatocellular carcinoma (HCC), affecting healthy children and young adults that often presents at an… read more here.
Keywords: fibrolamellar carcinoma; flc; external beam; radiation ... See more keywords
An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.44187
Abstract: Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A. Biochemical analyses of clinical samples reveal… read more here.
Keywords: dnaj pkac; scaffolding function; fibrolamellar carcinoma; acquired scaffolding ... See more keywords