Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning
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DOI: 10.1126/sciadv.aaz6197
Abstract: Specialized leader cells use stable filopodia to create linear fibronectin tracks to promote collective cancer invasion. Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here,… read more here.
Keywords: invasion; leader cells; collective invasion; fibronectin micropatterning ... See more keywords