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   Articles with "fibrosis" as a keyword



Cardiomyopathy in Muscular Dystrophy: When to Treat?

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recommendations! Published in 2017 at "JAMA cardiology"

DOI: 10.1001/jamacardio.2016.4910

Abstract: Duchenne muscular dystrophy (DMD) is a rare, X-linked condition with progressive muscle weakness and accompanying cardiomyopathy. Cardiovascular magnetic resonance (CMR) has proved particularly useful for monitoring the earliest signs of cardiac involvement in DMD, including… read more here.

Keywords: dmd; fibrosis; cardiology; muscular dystrophy ... See more keywords

Association of Body Mass Index With Clinical Outcomes in Patients With Cystic Fibrosis

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2022.0740

Abstract: Key Points Question Is higher-than-normal body mass index (BMI) associated with better clinical outcomes in patients with cystic fibrosis? Findings In this systematic review and meta-analysis of studies including 9114 patients with cystic fibrosis, BMI… read more here.

Keywords: clinical outcomes; patients cystic; body mass; mass index ... See more keywords

Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery

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recommendations! Published in 2017 at "JAMA Ophthalmology"

DOI: 10.1001/jamaophthalmol.2017.3407

Abstract: Importance Postsurgical fibrosis is a critical determinant of the long-term success of glaucoma surgery, but no reliable biomarkers are currently available to stratify the risk of scarring. Objective To compare the clinical phenotype of patients… read more here.

Keywords: glaucoma surgery; phenotype; fibrosis; glaucoma ... See more keywords

Enhanced Ferritin‐Manganese Interaction by Nanoplatinum Growth Enabling Liver Fibrosis 3D Magnetic Resonance Visualization and Synergistic Therapy with Real‐Time Monitoring

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recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202410748

Abstract: Early detection and timely intervention are essential to prevent liver fibrosis from progressing to cirrhosis or hepatocellular carcinoma. Herein, utilizing the enhanced ferritin‐manganese interaction by nanoplatinum growth, a novel ferritin‐platinum‐manganese magnetic resonance nanoplatform with RGD… read more here.

Keywords: liver fibrosis; magnetic resonance; fibrosis; real time ... See more keywords

Fibrosis‐on‐Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202303991

Abstract: Fibrosis, which is primarily marked by excessive extracellular matrix (ECM) deposition, is a pathophysiological process associated with many disorders, which ultimately leads to organ dysfunction and poor patient outcomes. Despite the high prevalence of fibrosis,… read more here.

Keywords: disease; chip guide; fibrosis; fibrotic diseases ... See more keywords

3D Humanized Bioprinted Tubulointerstitium Model to Emulate Renal Fibrosis In Vitro

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202400807

Abstract: Chronic kidney disease (CKD) leads to a gradual loss of kidney function, with fibrosis as pathological endpoint, which is characterized by extracellular matrix (ECM) deposition and remodeling. Traditionally, in vivo models are used to study… read more here.

Keywords: bioprinted tubulointerstitium; fibrosis; model; humanized bioprinted ... See more keywords

Fibrosis‐Encapsulated Tumoroid, A Solid Cancer Assembloid Model for Cancer Research and Drug Screening

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202402391

Abstract: Peritumoral fibrosis is known to promote cancer progression and confer treatment resistance in various solid tumors. Consequently, developing accurate cancer research and drug screening models that replicate the structure and function of a fibrosis‐surrounded tumor… read more here.

Keywords: research drug; cancer; fibrosis; cancer research ... See more keywords

Ultrasound‐Mediated Biomimetic Microbubbles Effectively Reverse LSECs Capillarization and Exert Antiplatelet Therapy in Liver Fibrosis

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202500196

Abstract: Liver fibrosis, characterized by excessive tissue remodeling as a response to chronic liver injury, is accompanied by capillarization of liver sinusoidal endothelial cells (LSECs) and activated hepatic stellate cells (HSCs). Simvastatin (Sim) can modulate endothelial… read more here.

Keywords: fibrosis; capillarization; mediated biomimetic; liver fibrosis ... See more keywords

Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis

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recommendations! Published in 2023 at "Advanced Materials"

DOI: 10.1002/adma.202212206

Abstract: During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit substance exchange between the blood and the Disse space, further accelerating hepatic stellate cell (HSCs) activation and fibrosis progression. Limited accessibility of… read more here.

Keywords: liver fibrosis; delivery anti; ignp jq1; treatment ... See more keywords

Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence

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recommendations! Published in 2024 at "Advanced Materials"

DOI: 10.1002/adma.202406590

Abstract: Hepatic fibrosis progresses concomitantly with a variety of biomechanical alternations, especially increased liver stiffness. These biomechanical alterations have long been considered as pathological consequences. Recently, growing evidence proposes that these alternations result in the fibrotic… read more here.

Keywords: biomechanical microenvironment; fibrosis; fibrotic biomechanical; microenvironment ... See more keywords

Legumain In Situ Engineering Promotes Efferocytosis of CAR Macrophage to Treat Cardiac Fibrosis

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recommendations! Published in 2025 at "Advanced Materials"

DOI: 10.1002/adma.202417831

Abstract: Uncontrolled and excessive cardiac fibrosis after myocardial infarction (MI) is a primary contributor to mortality by heart failure. Chimeric antigen receptor macrophage (CAR‐MΦ) therapy shows great promise in cardiac fibrosis, however, the overwhelming apoptotic cells… read more here.

Keywords: fibrosis; macrophage; car; cardiac fibrosis ... See more keywords