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   Articles with "fibrosis" as a keyword



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Cardiomyopathy in Muscular Dystrophy: When to Treat?

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recommendations! Published in 2017 at "JAMA cardiology"

DOI: 10.1001/jamacardio.2016.4910

Abstract: Duchenne muscular dystrophy (DMD) is a rare, X-linked condition with progressive muscle weakness and accompanying cardiomyopathy. Cardiovascular magnetic resonance (CMR) has proved particularly useful for monitoring the earliest signs of cardiac involvement in DMD, including… read more here.

Keywords: dmd; fibrosis; cardiology; muscular dystrophy ... See more keywords
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Association of Body Mass Index With Clinical Outcomes in Patients With Cystic Fibrosis

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2022.0740

Abstract: Key Points Question Is higher-than-normal body mass index (BMI) associated with better clinical outcomes in patients with cystic fibrosis? Findings In this systematic review and meta-analysis of studies including 9114 patients with cystic fibrosis, BMI… read more here.

Keywords: clinical outcomes; patients cystic; body mass; mass index ... See more keywords
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Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery

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recommendations! Published in 2017 at "JAMA Ophthalmology"

DOI: 10.1001/jamaophthalmol.2017.3407

Abstract: Importance Postsurgical fibrosis is a critical determinant of the long-term success of glaucoma surgery, but no reliable biomarkers are currently available to stratify the risk of scarring. Objective To compare the clinical phenotype of patients… read more here.

Keywords: glaucoma surgery; phenotype; fibrosis; glaucoma ... See more keywords
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Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis

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recommendations! Published in 2023 at "Advanced Materials"

DOI: 10.1002/adma.202212206

Abstract: During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit substance exchange between the blood and the Disse space, further accelerating hepatic stellate cell (HSCs) activation and fibrosis progression. Limited accessibility of… read more here.

Keywords: liver fibrosis; delivery anti; ignp jq1; treatment ... See more keywords
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Autologous Skin Fibroblast‐Based PLGA Nanoparticles for Treating Multiorgan Fibrosis

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202200856

Abstract: Fibrotic diseases remain a substantial health burden with few therapeutic approaches. A hallmark of fibrosis is the aberrant activation and accumulation of myofibroblasts, which is caused by excessive profibrotic cytokines. Conventional anticytokine therapies fail to… read more here.

Keywords: autologous skin; skin; skin fibroblast; fibrosis ... See more keywords
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Scar‐Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202203315

Abstract: Deposition of extracellular matrix (ECM) in the liver is an important feature of liver cirrhosis. Recovery from liver cirrhosis is physiologically challenging, partially due to the ECM in scar tissue showing resistance to cell‐mediated degradation… read more here.

Keywords: liver fibrosis; endothelial cells; degrading endothelial; advanced liver ... See more keywords
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Comment on "Scar-Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis".

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202207396

Abstract: Cellular therapies show promise for treatment of fibrosis. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. A discussion is presented surrounding the strengths of this… read more here.

Keywords: scar degrading; endothelial cells; comment scar; treatment ... See more keywords
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Development of skeletal muscle fibrosis in a rodent model of cancer cachexia.

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recommendations! Published in 2023 at "Cell biochemistry and function"

DOI: 10.1002/cbf.3797

Abstract: Cachexia is characterized by losses in lean body mass and its progression results in worsened quality of life and exacerbated outcomes in cancer patients. However, the role and impact of fibrosis during the early stages… read more here.

Keywords: tumor; development; skeletal muscle; mice ... See more keywords
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Peptide‐Based Nanoarchitectonics for the Treatment of Liver Fibrosis

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recommendations! Published in 2023 at "ChemBioChem"

DOI: 10.1002/cbic.202300002

Abstract: Liver fibrosis is a process of excessive accumulation of extracellular matrix caused by liver injury. Liver fibrosis can progress to cirrhosis or even liver cancer without proper intervention. Until now, no effective therapeutic drugs have… read more here.

Keywords: peptide based; liver fibrosis; based nanoarchitectonics; nanoarchitectonics treatment ... See more keywords
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The paired‐related homeobox protein 1 promotes cardiac fibrosis via the Twist1‐Prrx1‐tenascin‐C loop

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11944

Abstract: Cardiac fibrosis is a common pathology in the advanced stage of cardiovascular diseases, which leads to cardiac systolic and diastolic dysfunction. It is important to prevent cardiac fibrosis during myocardial injury. The transcription factor Prrx1… read more here.

Keywords: prrx1; cardiac fibrosis; paired related; twist1 prrx1 ... See more keywords
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Crosstalk between myofibroblasts and macrophages: A regulative factor of valvular fibrosis in calcific aortic valve disease

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11980

Abstract: Inflammation and fibrosis are highly correlated with the progression of calcific aortic valve disease (CAVD). As one of the differentiated forms of valvular interstitial cells, myofibroblasts play a critical role in CAVD's development as do… read more here.

Keywords: aortic valve; myofibroblasts macrophages; valve disease; crosstalk myofibroblasts ... See more keywords