Hepatocyte autotaxin expression promotes liver fibrosis and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28973
Abstract: Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased ATX expression has been detected in various chronic inflammatory disorders and different types of cancer;… read more here.
Keywords: atx; liver fibrosis; fibrosis cancer; expression ... See more keywords
Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21596
Abstract: Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus, effective therapeutic strategies are urgently needed. Because drug resistance has been widely reported in fibrotic tissue and cancer, developing a strategy to… read more here.
Keywords: mesenchymal transition; fibrosis; treatment; fibrosis cancer ... See more keywords
ZEB1: New advances in fibrosis and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-020-04036-7
Abstract: Zinc finger E-box binding homeobox 1 (ZEB1) is an important transcription factor in epithelial mesenchymal transition (EMT) which participates in the numerous life processes, such as embryonic development, fibrosis and tumor progression. ZEB1 has multiple… read more here.
Keywords: new advances; fibrosis cancer; fibrosis; zeb1 new ... See more keywords
A New Positive Feedback Circuit in the Fibrosis–Cancer Axis for Male Livers
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2017.02.007
Abstract: erotonin (also known as 5-hydroxytryptamine S[5-HT]) is a small-molecule neurotransmitter that was identified in a series of studies conducted between 1935 and 1953 because of its capacity to induce contractions in the intestine and blood… read more here.
Keywords: fibrosis; gastroenterology; serotonin; fibrosis cancer ... See more keywords
Is idiopathic pulmonary fibrosis a cancer-like disease? Transcriptome analysis to fuel the debate
Sign Up to like & getrecommendations! Published in 2019 at "ERJ Open Research"
DOI: 10.1183/23120541.00157-2018
Abstract: Idiopathic pulmonary fibrosis (IPF) is a devastating and eventually fatal diffuse parenchymal lung disorder that largely remains refractory to pharmacological therapies [1]. IPF is characterised by excessive fibroblast proliferation leading to the formation of fibroblast… read more here.
Keywords: treatment modalities; idiopathic pulmonary; fibrosis cancer; pulmonary fibrosis ... See more keywords
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer"
DOI: 10.1186/s12943-022-01569-x
Abstract: Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis. The role of TGF-β in fibrosis and cancer is… read more here.
Keywords: targeting tgf; tgf; cancer; tgf signal ... See more keywords
Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom11010017
Abstract: The human gastrointestinal tract contains the largest population of immune cells in the body and this is a reflection of the fact that it is continuously exposed to a myriad of dietary and bacterial antigens.… read more here.
Keywords: cancer; gut inflammation; fibrosis cancer; role tgf ... See more keywords
The SLIT/ROBO Pathway in Liver Fibrosis and Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050785
Abstract: Liver fibrosis is a common outcome of most chronic liver insults/injuries that can develop into an irreversible process of cirrhosis and, eventually, liver cancer. In recent years, there has been significant progress in basic and… read more here.
Keywords: liver fibrosis; slit robo; robo pathway; fibrosis cancer ... See more keywords
Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416109
Abstract: Gastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of… read more here.
Keywords: fibrosis cancer; disease; fibrosis; inflammation fibrosis ... See more keywords
LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Non-Coding RNA"
DOI: 10.3390/ncrna8030036
Abstract: Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney… read more here.
Keywords: fibrosis cancer; tgf; cancer; tissue fibrosis ... See more keywords