Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
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DOI: 10.1021/acs.jmedchem.1c01897
Abstract: In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant protein. These defects can be targeted with pharmacological agents… read more here.
Keywords: proteostasis regulators; proteostasis; fibrosis current; regulators cystic ... See more keywords
Understanding Drivers of Ocular Fibrosis: Current and Future Therapeutic Perspectives
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111748
Abstract: Ocular fibrosis leads to severe visual impairment and blindness worldwide, being a major area of unmet need in ophthalmology and medicine. To date, the only available treatments are antimetabolite drugs that have significant potentially blinding… read more here.
Keywords: fibrosis current; fibrosis; understanding drivers; ocular fibrosis ... See more keywords