Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway
Sign Up to like & getrecommendations! Published in 2017 at "Human Cell"
DOI: 10.1007/s13577-017-0192-8
Abstract: Diabetic nephropathy (DN) is the major cause of end-stage renal disease in diabetic patients. Zicao, a well-known Chinese traditional medicine, has attracted much attention due to its beneficial effects in various medical fields. In this… read more here.
Keywords: acetylshikonin; diabetic mice; renal dysfunction; fibrosis diabetic ... See more keywords
Periostin-binding DNA aptamer treatment attenuates renal fibrosis under diabetic conditions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09238-6
Abstract: Diabetic nephropathy, the major cause of chronic kidney disease, is associated with progressive renal fibrosis. Recently, accumulation of periostin, an extracellular matrix protein, was shown to augment renal fibrosis. Aptamers have higher binding affinities without… read more here.
Keywords: fibrosis; treatment; renal fibrosis; dna aptamer ... See more keywords