Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770
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DOI: 10.1002/cmdc.202000220
Abstract: Although the 1,2,3‐triazole is a commonly used amide bioisostere in medicinal chemistry, the structural implications of this replacement have not been fully studied. Employing X‐ray crystallography and computational studies, we report the spatial and electronic… read more here.
Keywords: cystic fibrosis; fibrosis drugs; analogues cystic; amide bioisostere ... See more keywords
Cystic fibrosis drugs target the malformed proteins at the root of the disease
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DOI: 10.1038/d41586-020-02106-w
Abstract: New combinations of molecules put many patients on the path to good health. But those with rarer mutations are, for now, left behind. New combinations of molecules put many patients on the path to good… read more here.
Keywords: malformed proteins; cystic fibrosis; target malformed; fibrosis drugs ... See more keywords