The airway microbiota in early cystic fibrosis lung disease
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.23782
Abstract: Infection plays a critical role in the pathogenesis of cystic fibrosis (CF) lung disease. Over the past two decades, the application of molecular and extended culture‐based techniques to microbial analysis has changed our understanding of… read more here.
Keywords: cystic fibrosis; lung disease; disease; fibrosis lung ... See more keywords
Cystic fibrosis lung transplant recipients 10 years of age or younger: Predisposing factors for end‐stage disease
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.25882
Abstract: The largest age group among children and adolescents referred for lung transplantation for cystic fibrosis (CF) have been those in the pubertal or postpubertal age range. However, over 100 younger patients with CF have undergone… read more here.
Keywords: lung transplant; fibrosis lung; cystic fibrosis; age ... See more keywords
Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota
Sign Up to like & getrecommendations! Published in 2020 at "Nature Microbiology"
DOI: 10.1038/s41564-019-0643-y
Abstract: Amplicon sequencing (for example, of the 16S rRNA gene) identifies the presence and relative abundance of microbial community members. However, metagenomic sequencing is needed to identify the genetic content and functional potential of a community.… read more here.
Keywords: cystic fibrosis; metagenomic sequencing; culture enriched; fibrosis lung ... See more keywords
Multiprobe Nuclear Imaging of the Cystic Fibrosis Lung as a Biomarker of Therapeutic Effect.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of aerosol medicine and pulmonary drug delivery"
DOI: 10.1089/jamp.2018.1491
Abstract: BACKGROUND Nuclear imaging biomarkers illustrate unique aspects of lung physiology and are useful for assessing therapeutic effects in cystic fibrosis (CF) lung disease. We have developed a multiprobe method to simultaneously measure mucociliary clearance (MCC)… read more here.
Keywords: cystic fibrosis; mcc; nuclear imaging; fibrosis lung ... See more keywords
Untargeted Metabolomics Reveals Species-Specific Metabolite Production and Shared Nutrient Consumption by Pseudomonas aeruginosa and Staphylococcus aureus
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DOI: 10.1128/msystems.00480-21
Abstract: Interactions between P. aeruginosa and S. aureus can impact pathogenicity and antimicrobial efficacy. In this study, we aim to better understand the potential for metabolic interactions between P. aeruginosa and S. aureus in an environment… read more here.
Keywords: aeruginosa aureus; species specific; cystic fibrosis; fibrosis lung ... See more keywords
Assessment of fibrosis in lung biopsies from the European childhood interstitial lung disease (chILD) registry
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2020.5257
Abstract: Introduction: chILD comprises various rare respiratory conditions and partially overlaps with adult ILD. Lung fibrosis is the most common disease entity in adults; however, there are no data on the prevalence, clinical, radiological and histopathological… read more here.
Keywords: fibrosis; lung biopsies; child; disease ... See more keywords