Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01271-7
Abstract: BackgroundOrgan crosstalk can be defined as the complex and mutual biological communication between distant organs mediated by signaling factors. Normally, crosstalk helps to coordinate and maintain homeostasis, but sudden or chronic dysfunction in any organ… read more here.
Keywords: fibrotic changes; organ crosstalk; organ interactions; crosstalk ... See more keywords
Sustained dasatinib treatment prevents early fibrotic changes following ocular trauma
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-020-05037-4
Abstract: Posterior ocular trauma and the subsequent fibrotic retinal complication termed proliferative vitreoretinopathy (PVR) are leading causes of blindness in children and young adults. A previous study suggested that changes occurring within the first month post-trauma… read more here.
Keywords: fibrotic changes; following ocular; early fibrotic; ocular trauma ... See more keywords
Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.12.014
Abstract: OBJECTIVE We have reported that fibrotic changes in infrapatellar fat pad (IFP) after acute joint inflammation are closely associated with persistent pain in rats. In this study, to examine the effects of anti-fibrotic treatment on… read more here.
Keywords: fibrotic changes; persistent pain; articular cartilage; cartilage degeneration ... See more keywords
Long non-coding RNA FABP5P3/miR-22 axis improves TGFβ1-induced fatty acid oxidation deregulation and fibrotic changes in proximal tubular epithelial cells of renal fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2122286
Abstract: ABSTRACT Severe hydronephrosis increases the risk of urinary tract infection and irretrievable renal fibrosis. While TGFβ1-mediated fibrotic changes in proximal tubular epithelial cells and fatty acid oxidation (FAO) deregulation contribute to renal fibrosis and hydronephrosis.… read more here.
Keywords: lncrna fabp5p3; renal fibrosis; fibrotic changes; tgf induced ... See more keywords
Copper nanoparticles induce early fibrotic changes in the liver via TGF-β/Smad signaling and cause immunosuppressive effects in rats
Sign Up to like & getrecommendations! Published in 2018 at "Nanotoxicology"
DOI: 10.1080/17435390.2018.1472313
Abstract: Abstract Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by… read more here.
Keywords: fibrotic changes; tgf smad; smad signaling; tgf ... See more keywords
Computed Tomography-Based Quantitative Analysis of Fibrotic Changes in Skin and Subcutaneous Tissue in Lower Extremity Lymphedema Following Gynecologic Cancer Surgery.
Sign Up to like & getrecommendations! Published in 2022 at "Lymphatic research and biology"
DOI: 10.1089/lrb.2021.0069
Abstract: Background: Lymphedema produces protein-rich fluids that aggravate inflammation in the skin and subcutaneous tissue. Inflammation then induces fibroadipose tissue deposition and fibrosis. However, few methods have been developed to evaluate the severity of fibrosis. Therefore,… read more here.
Keywords: lymphedema following; subcutaneous tissue; fibrotic changes; following gynecologic ... See more keywords
Activation of TRPA1 in Bladder Suburothelial Myofibroblasts Counteracts TGF-β1-Induced Fibrotic Changes
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119501
Abstract: The activation of the transient receptor potential ankyrin 1 (TRPA1) channel has anti-fibrotic effects in the lung and intestine. Suburothelial myofibroblasts (subu−MyoFBs), a specialized subset of fibroblasts in the bladder, are known to express TRPA1.… read more here.
Keywords: induced fibrotic; trpa1; bladder; suburothelial myofibroblasts ... See more keywords