Genetic and Epidemiological Similarities, and Differences Between Postoperative Intraperitoneal Adhesion Development and Other Benign Fibro-proliferative Disorders
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Sciences"
DOI: 10.1007/s43032-021-00726-9
Abstract: Intraperitoneal adhesions complicate over half of abdominal-pelvic surgeries with immediate, short, and long-term sequelae of major healthcare concern. The pathogenesis of adhesion development is similar to the pathogenesis of wound healing in all tissues, which… read more here.
Keywords: fibrotic diseases; adhesion; epidemiological similarities; genetic epidemiological ... See more keywords
Shared and distinct mechanisms of fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-019-0322-7
Abstract: Fibrosis is defined as an excessive deposition of connective tissue components and can affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue remodelling often leads to organ malfunction and is… read more here.
Keywords: fibrotic diseases; fibrosis; tissue; growth factor ... See more keywords
HSP47: a potential target for fibrotic diseases and implications for therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2021.1861249
Abstract: Introduction: Chronic fibrotic disorders are challenging clinical problems. The major challenge is the identification of specific targets expressed selectively in fibrotic tissues to avoid potential side effects of inhibiting ubiquitous factors in healthy tissues. Extensive… read more here.
Keywords: collagen; fibrotic diseases; fibrosis; target ... See more keywords
Therapeutic potential of NADPH oxidase 1/4 inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13532
Abstract: The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role… read more here.
Keywords: inflammatory fibrotic; oxidase; fibrotic diseases; range ... See more keywords
Research Progress of Fibroblast Growth Factor 21 in Fibrotic Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5042762
Abstract: Fibrosis is a common pathological outcome of chronic injuries, characterized by excessive deposition of extracellular matrix components in organs, as seen in most chronic inflammatory diseases. At present, there is an increasing tendency of the… read more here.
Keywords: factor; growth factor; fibrotic diseases; fibrosis ... See more keywords
The contribution of the immune system to genitourinary fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221090872
Abstract: Fibrotic diseases of the genitourinary tract are devastating and incompletely understood pathologies. These diseases include urethral and ureteral strictures, retroperitoneal fibrosis, and Peyronie’s disease. They can contribute to obstructive uropathy and sexual dysfunction. Poor understanding… read more here.
Keywords: system; contribution immune; fibrotic diseases; fibrosis ... See more keywords
HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/2040622319862697
Abstract: Fibrosis usually results from dysregulated wound repair and is characterized by excessive scar tissue. It is a complex process with unclear mechanisms. Accumulating evidence indicates that epigenetic alterations, including histone acetylation, play a pivotal role… read more here.
Keywords: fibrotic diseases; fibrosis; cardiac pulmonary; hdac inhibitors ... See more keywords
CD248: A therapeutic target in cancer and fibrotic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26590
Abstract: CD248/endosialin/TEM1 is a type 1 transmembrane glycoprotein found on the plasma membrane of activated mesenchymal cells. CD248 functions during embryo development and is either not expressed or found at very low levels in adult tissues.… read more here.
Keywords: fibrotic diseases; diseases cd248; cd248 therapeutic; target cancer ... See more keywords
Possible disease-protective roles of fibroblasts in cancer and fibrosis and their therapeutic application
Sign Up to like & getrecommendations! Published in 2022 at "Nagoya Journal of Medical Science"
DOI: 10.18999/nagjms.84.3.484
Abstract: ABSTRACT Cancer and fibrotic diseases are characterized by continuous inflammation, tissue wounds, and injuries. Cancer is a “wound that does not heal,” and the uncontrolled proliferation of cancer cells disrupts normal tissue integrity and induces… read more here.
Keywords: disease; cancer fibrotic; possible disease; fibrotic diseases ... See more keywords
Role of Ferroptosis in Fibrotic Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s358470
Abstract: Abstract Ferroptosis is a unique and pervasive form of regulated cell death driven by iron-dependent phospholipid peroxidation. It results from disturbed cellular metabolism and imbalanced redox homeostasis and is regulated by various cellular metabolic pathways.… read more here.
Keywords: ferroptosis fibrotic; role ferroptosis; fibrotic diseases; ferroptosis ... See more keywords
Identification of Common Genes and Pathways in Eight Fibrosis Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.627396
Abstract: Acute and chronic inflammation often leads to fibrosis, which is also the common and final pathological outcome of chronic inflammatory diseases. To explore the common genes and pathogenic pathways among different fibrotic diseases, we collected… read more here.
Keywords: eight fibrotic; fibrotic diseases; fibrosis; enrichment scores ... See more keywords