Fibrotic Hypersensitivity Pneumonitis: Diagnosis and Management
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DOI: 10.1007/s00408-020-00360-3
Abstract: Fibrotic hypersensitivity pneumonitis is a complex interstitial lung disease that is not entirely understood. In its chronic and fibrotic form, hypersensitivity pneumonitis is one of the main mimickers of idiopathic pulmonary fibrosis (IPF). Distinguishing between… read more here.
Keywords: fibrotic hypersensitivity; hypersensitivity pneumonitis; management; hypersensitivity ... See more keywords
Management of fibrotic hypersensitivity pneumonitis
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DOI: 10.1097/mcp.0000000000000904
Abstract: Purpose of review Recent guidelines have updated the classification of hypersensitivity pneumonitis, stratifying by the presence or absence of fibrosis as either fibrotic or nonfibrotic hypersensitivity pneumonitis. Fibrotic hypersensitivity pneumonitis represents up to 10% of… read more here.
Keywords: hypersensitivity pneumonitis; hypersensitivity; management fibrotic; fibrotic hypersensitivity ... See more keywords
Short‐term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis
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DOI: 10.1111/resp.14204
Abstract: A proportion of patients with fibrotic hypersensitivity pneumonitis (fHP) follow a progressive disease course despite immunosuppressive treatment. Little is known about predictors of mortality in fHP. We aimed to investigate the impact of short‐term lung… read more here.
Keywords: short term; hypersensitivity pneumonitis; mortality; patients fibrotic ... See more keywords
Pirfenidone in fibrotic hypersensitivity pneumonitis: a double-blind, randomised clinical trial of efficacy and safety
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DOI: 10.1136/thorax-2022-219795
Abstract: Background Fibrotic hypersensitivity pneumonitis (FHP) is an irreversible lung disease with high morbidity and mortality. We sought to evaluate the safety and effect of pirfenidone on disease progression in such patients. Methods We conducted a… read more here.
Keywords: hypersensitivity pneumonitis; safety; trial; pirfenidone ... See more keywords
B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding
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DOI: 10.1159/000527533
Abstract: Introduction: We investigated the molecular mechanism by which B lymphocytes regulate Th1/Th2 imbalance to participate in the pulmonary fibrosis in hypersensitivity pneumonia induced by pigeon shedding in rats. Methods: CD19+ rats and CD19− rats were… read more here.
Keywords: hypersensitivity pneumonia; cd19 rats; pneumonia; th1 th2 ... See more keywords
Diagnosis and Treatment of Fibrotic Hypersensitivity Pneumonia. Where We Stand and Where We Need to Go
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DOI: 10.1164/rccm.201608-1675pp
Abstract: Diagnosis and Treatment of Fibrotic Hypersensitivity Pneumonia Where We Stand and Where We Need to Go Margaret L. Salisbury, Jeffrey L. Myers, Elizabeth A. Belloli, Ella A. Kazerooni, Fernando J. Martinez, and Kevin R. Flaherty… read more here.
Keywords: medicine; diagnosis treatment; pneumonia stand; fibrotic hypersensitivity ... See more keywords
Variable utility of mosaic attenuation to distinguish fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis
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DOI: 10.1183/13993003.00531-2019
Abstract: Background Mosaic attenuation on computed tomography (CT) has been identified in international guidelines as an important diagnostic feature of fibrotic hypersensitivity pneumonitis (FHP) as opposed to idiopathic pulmonary fibrosis (IPF). However, mosaic attenuation comprises several… read more here.
Keywords: idiopathic pulmonary; fibrotic hypersensitivity; hypersensitivity pneumonitis; attenuation ... See more keywords
Antigen identification and avoidance on outcomes in fibrotic hypersensitivity pneumonitis
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DOI: 10.1183/13993003.01336-2021
Abstract: Background Suspected causative antigens may be unidentified in 30–50% of patients with fibrotic hypersensitivity pneumonitis (f-HP). It is unclear whether antigen identification and avoidance in this setting offer any additional clinical benefit. We hypothesised that… read more here.
Keywords: identification avoidance; antigen identification; identification; fibrotic hypersensitivity ... See more keywords
Fibrotic Hypersensitivity Pneumonitis Diagnosed by a Re-evaluation with Bronchoalveolar Lavage at Disease Deterioration
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DOI: 10.2169/internalmedicine.9736-22
Abstract: A 79-year-old man was admitted with worsening cough, dyspnea, and increased ground-glass opacity on chest computed tomography (CT). He had been diagnosed with idiopathic pulmonary fibrosis given the absence of an identifiable cause of interstitial… read more here.
Keywords: hypersensitivity pneumonitis; evaluation; bronchoalveolar lavage; fibrotic hypersensitivity ... See more keywords
Bronchoalveolar Lavage Cell Count and Lymphocytosis Are the Important Discriminators between Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis
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DOI: 10.3390/diagnostics13050935
Abstract: Background: Fibrotic hypersensitivity pneumonitis (fHP) shares many features with other fibrotic interstitial lung diseases (ILD), and as a result it can be misdiagnosed as idiopathic pulmonary fibrosis (IPF). We aimed to determine the value of… read more here.
Keywords: hypersensitivity pneumonitis; idiopathic pulmonary; pulmonary fibrosis; fibrotic hypersensitivity ... See more keywords
Diagnosis of Fibrotic Hypersensitivity Pneumonitis: Is There a Role for Biomarkers?
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DOI: 10.3390/life13020565
Abstract: Hypersensitivity pneumonitis is a complex interstitial lung syndrome and is associated with significant morbimortality, particularly for fibrotic disease. This condition is characterized by sensitization to a specific antigen, whose early identification is associated with improved… read more here.
Keywords: hypersensitivity pneumonitis; role; fibrotic hypersensitivity; hypersensitivity ... See more keywords