Interleukin-6–dependent epithelial fluidization initiates fibrotic lung remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo5254
Abstract: Chronic disease results from the failure of tissues to maintain homeostasis. In the lung, coordinated repair of the epithelium is essential for preserving homeostasis. In animal models and human lung disease, airway epithelial cells mobilize… read more here.
Keywords: airway epithelial; fibrotic lung; fluidization; lung ... See more keywords
Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-resolution Computed Tomography.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202112-2684oc
Abstract: RATIONALE Reliable outcome prediction in patients with fibrotic lung disease using baseline high-resolution computed tomography (HRCT) data remains challenging. OBJECTIVES To evaluate the prognostic accuracy of a deep learning algorithm (SOFIA), trained and validated in… read more here.
Keywords: outcome prediction; disease; fibrotic lung; lung ... See more keywords
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152690
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by collagen deposition within the lung interstitium. Bacterial infection is associated with increased morbidity and more rapid mortality in IPF patient populations, and pathogens… read more here.
Keywords: immune responses; disease; fibrotic lung; impaired neutrophil ... See more keywords
Vascular permeability in the fibrotic lung
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.00100-2019
Abstract: Idiopathic pulmonary fibrosis (IPF) is thought to result from aberrant tissue repair processes in response to chronic or repetitive lung injury. The origin and nature of the injury, as well as its cellular and molecular… read more here.
Keywords: endothelial permeability; fibrotic lung; permeability; lung injury ... See more keywords
Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis
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DOI: 10.1183/16000617.0022-2019
Abstract: Two antifibrotic medications (nintedanib and pirfenidone) were recommended (conditionally) for the treatment of patients with idiopathic pulmonary fibrosis (IPF) in the 2015 IPF evidence-based guidelines. These medications have been shown to reduce the rate of… read more here.
Keywords: fibrotic lung; idiopathic pulmonary; non ipf; disease ... See more keywords
Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-017-0455-x
Abstract: BackgroundDecorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue… read more here.
Keywords: fibrotic lung; serum biomarker; degraded decorin; decorin ... See more keywords
COVID-19: Unilateral Involvement of Transplanted Lung, Sparing Contralateral Fibrotic Lung
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Clinical Infectious Diseases"
DOI: 10.5812/archcid.115408
Abstract: Introduction: Organ transplant recipients might be more likely to develop COVID-19, as they receive long-term immunosuppressives and have comorbidities. Case Presentation: Herein, we reported the case of a 32-year-old man with unilateral lung transplantation due… read more here.
Keywords: lung; transplanted lung; unilateral involvement; fibrotic lung ... See more keywords