Eliminating Regurgitation Reduces Fibrotic Remodeling of Functional Mitral Regurgitation Conditioned Valves
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-018-1987-9
Abstract: Functional mitral regurgitation (FMR) is an insidious and poorly understood condition affecting patients with myocardial disease. While current treatments reduce regurgitation, their ability to reverse mitral valve pathology is unclear. We utilized a pseudo-physiological flow… read more here.
Keywords: regurgitation; functional mitral; fibrotic remodeling; mitral regurgitation ... See more keywords
Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2019-0358oc
Abstract: Surfactant protein C (SP-C) deficiency is found in samples from patients suffering idiopathic pulmonary fibrosis (IPF), especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling in aging mice… read more here.
Keywords: cholesterol metabolism; fibrotic remodeling; cholesterol; surfactant protein ... See more keywords
LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.75200
Abstract: Rationale: The transformation of fibroblasts into activated myofibroblasts is a critical step that results in cardiac fibrosis upon myocardial infarction (MI). Leucine-rich repeat-containing protein-8A (LRRC8A) is a multi-functional protein involved in cell survival, growth, and… read more here.
Keywords: fibrotic remodeling; cardiac fibrosis; lrrc8a; myocardial infarction ... See more keywords