Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes
Sign Up to like & getrecommendations! Published in 2022 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfac237
Abstract: ABSTRACT Background Common genetic variants of the enzymes and efflux pump involved in tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but their importance is unclear because of the multifactorial background of renal fibrosis.… read more here.
Keywords: fibrotic response; background; pro fibrotic; tacrolimus ... See more keywords
Myofibroblast-Specific TGF&bgr; Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy
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DOI: 10.1161/circresaha.118.313089
Abstract: Rationale: Hypertrophic cardiomyopathy occurs with a frequency of about 1 in 500 people. Approximately 30% of those affected carry mutations within the gene encoding cMyBP-C (cardiac myosin binding protein C). Cardiac stress, as well as… read more here.
Keywords: myofibroblast specific; fibrotic response; myofibroblast; mybpc340kda ... See more keywords
The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner
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DOI: 10.3390/biom12091181
Abstract: The signaling inputs that function to integrate biochemical and mechanical cues from the extracellular environment to alter the wound-repair outcome to a fibrotic response remain poorly understood. Here, using a clinically relevant post-cataract surgery wound… read more here.
Keywords: pi3k isoform; fibrotic response; role; isoform specific ... See more keywords