Bcl10 Regulates Lipopolysaccharide-Induced Pro-Fibrotic Signaling in Bronchial Fibroblasts from Severe Asthma Patients
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DOI: 10.3390/biomedicines10071716
Abstract: Subepithelial fibrosis is a characteristic hallmark of airway remodeling in asthma. Current asthma medications have limited efficacy in treating fibrosis, particularly in patients with severe asthma, necessitating a deeper understanding of the fibrotic mechanisms. The… read more here.
Keywords: bronchial fibroblasts; fibrotic signaling; fibrosis; pro fibrotic ... See more keywords
Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells
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DOI: 10.3390/ijms231911636
Abstract: Chronic liver inflammation can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Kupffer cells (KC) secrete proinflammatory and fibrogenic cytokines in response to lipopolysaccharide (LPS), and so play an important role in liver inflammation, where they… read more here.
Keywords: evogliptin directly; directly inhibits; inhibits inflammatory; fibrotic signaling ... See more keywords