Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-01974-z
Abstract: Fibulin-3 (F3) is an extracellular matrix glycoprotein found in basement membranes across the body. An autosomal dominant R345W mutation in F3 causes a macular dystrophy resembling dry age-related macular degeneration (AMD), whereas genetic removal of… read more here.
Keywords: knockout mice; mice; fibulin; retina rpe ... See more keywords
Relationship between the Plasma Fibulin-1 Levels, Pulse Wave Velocity, and Vascular Age in Asymptomatic Hyperuricemia
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2324-3
Abstract: Fibulin-1 (FBLN-1), an elastin-associated extracellular matrix protein, has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease (CVD). We aimed to investigate the relationship between fibulin-1 levels… read more here.
Keywords: patients ahu; vascular age; fibulin levels; plasma fibulin ... See more keywords
Fibulin-5 promotes airway smooth muscle cell proliferation and migration via modulating Hippo-YAP/TAZ pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.105
Abstract: Asthma is a common chronic disease mainly occurs from childhood. Increased airway smooth muscle mass is involved in the pathogenesis of asthma. Fibulin-5 was upregulated in the lung tissues of patients with COPD and idiopathic… read more here.
Keywords: yap taz; fibulin; proliferation migration;
Fibulin-3 affects vascular endothelial function and is regulated by angiotensin II.
Sign Up to like & getrecommendations! Published in 2020 at "Microvascular research"
DOI: 10.1016/j.mvr.2020.104043
Abstract: OBJECTIVE The aim of the present study was to investigate the effect of fibulin-3 on vascular endothelial function, and to explore the relevant underlying mechanism with regard to the involvement of angiotensin II (AngII). METHODS… read more here.
Keywords: endothelial function; vascular endothelial; serum fibulin; fibulin ... See more keywords
Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.06.014
Abstract: During amniote peripheral nervous system development, segmentation ensures the correct patterning of the spinal nerves relative to the vertebral column. Along the antero-posterior (rostro-caudal) axis, each somite-derived posterior half-sclerotome expresses repellent molecules to restrict axon… read more here.
Keywords: spinal nerve; matrix protein; axon growth; extracellular matrix ... See more keywords
Fibulin-3 promotes muscle-invasive bladder cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.149
Abstract: Urothelial carcinoma is the most common type of bladder cancer and can be categorized as either non-muscle-invasive (Ta-T1) or muscle-invasive (⩾T2). The majority of bladder cancers are non-muscle-invasive at presentation; however, the recurrence rate for… read more here.
Keywords: bladder cancer; invasive bladder; bladder; muscle invasive ... See more keywords
Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-00351-1
Abstract: The vagina plays a critical role in supporting the pelvic organs and loss of support leads to pelvic organ prolapse. It is unknown what microstructural changes influence prolapse progression nor how decreased elastic fibers contributes… read more here.
Keywords: prolapse progression; biomechanical function; prolapse; role ... See more keywords
Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20203097
Abstract: Abstract Survivin is an inhibitor of apoptosis as well as a promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein that displays potential for tumor suppression or propagation. The present study aimed to validate the… read more here.
Keywords: expression; group included; fibulin; survivin fibulin ... See more keywords
Efficacy of Shaobei injection in the treatment of grade II–III hemorrhoids and the effect on fibulin protein expression
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000027706
Abstract: Abstract Background: Hemorrhoids are a common and seriously disruptive condition that seriously affects people's lives in terms of treatment. Injection therapy is an effective minimally invasive scheme for the treatment of grade II–III hemorrhoids, but… read more here.
Keywords: shaobei injection; treatment grade; treatment; grade iii ... See more keywords
Dual antivascular function of human fibulin‐3 variant, a potential new drug discovery strategy for glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14300
Abstract: The ECM protein EFEMP1 (fibulin‐3) is associated with all types of solid tumor through its cell context‐dependent dual function. A variant of fibulin‐3 was engineered by truncation and mutation to alleviate its oncogenic function, specifically… read more here.
Keywords: fibulin variant; gbm; zr30; human fibulin ... See more keywords
Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4053873
Abstract: Competent elastic fibers are critical to the function of the lung and right circulation. Murine models of elastopathies can aid in understanding functional roles of the elastin and elastin-associated glycoproteins that constitute elastic fibers. Here,… read more here.
Keywords: function; deficient mice; function fibulin; fibulin ... See more keywords