KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.
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DOI: 10.1126/science.adn2337
Abstract: Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiation toward alternative fates… read more here.
Keywords: lineage fidelity; exhaustion; fidelity suppresses; infection ... See more keywords