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   Articles with "filament assembly" as a keyword



ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly

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recommendations! Published in 2025 at "Cell Research"

DOI: 10.1038/s41422-025-01183-8

Abstract: MDA5 is a RIG-I-like receptor (RLR) that recognizes viral double-stranded RNA (dsRNA) to initiate the innate immune response. Its activation requires filament formation along the dsRNA, which triggers the oligomerization of N-terminal caspase activation and… read more here.

Keywords: mda5; immune homeostasis; one dimensional; filament assembly ... See more keywords

Filament assembly of the C. elegans lamin in the absence of helix 1A

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recommendations! Published in 2022 at "Nucleus"

DOI: 10.1080/19491034.2022.2032917

Abstract: ABSTRACT Lamins are the major constituent of the nuclear lamina, a protein meshwork underlying the inner nuclear membrane. Nuclear lamins are type V intermediate filaments that assemble into ~3.5 nm thick filaments. To date, only… read more here.

Keywords: filament assembly; elegans lamin; assembly; assembly elegans ... See more keywords

A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation.

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recommendations! Published in 2025 at "Blood advances"

DOI: 10.1182/bloodadvances.2025016100

Abstract: Key Points • A novel short TNS1 isoform (eTNS1) with a unique primate-specific start exon 1E increases late in terminal erythroid differentiation.• CRISPR-associated protein 9 deletion of eTNS1 impairs F-actin assembly in orthochromatic erythroblasts and… read more here.

Keywords: filament assembly; tensin1 promotes; novel isoform; actin filament ... See more keywords

The Mechanisms of Thin Filament Assembly and Length Regulation in Muscles

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23105306

Abstract: The actin containing tropomyosin and troponin decorated thin filaments form one of the crucial components of the contractile apparatus in muscles. The thin filaments are organized into densely packed lattices interdigitated with myosin-based thick filaments.… read more here.

Keywords: mechanisms thin; thin filament; assembly length; thin filaments ... See more keywords