Age-dependent formation of TMEM106B amyloid filaments in human brains.
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DOI: 10.1038/s41586-022-04650-z
Abstract: Many age-dependent neurodegenerative diseases, like Alzheimer's and Parkinson's, are characterised by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β (Aβ), α-synuclein and TDP-43 are the most common1,2. Here, we used electron… read more here.
Keywords: tmem106b; age dependent; human brains; filaments human ... See more keywords
Cryo-EM structures of amyloid-β 42 filaments from human brains
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm7285
Abstract: Description Hi-res view of human Aβ42 filaments Alzheimer’s disease is characterized by a loss of memory and other cognitive functions and the filamentous assembly of Aβ and tau in the brain. The assembly of Aβ… read more here.
Keywords: filaments human; alzheimer disease; type filaments; microscopy ... See more keywords