ATPR‐induced G0/G1 phase arrest in gastric cancer cells by regulating the binding of 14‐3‐3ε and filamin A
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1583
Abstract: 4‐amino‐2‐trifluoromethyl‐phenyl retinate (ATPR) was able to induce the G0/G1 phase arrest in gastric cancer SGC‐7901 cells by downregulating 14‐3‐3ε. However, the mechanisms underlying this effect have not been fully elucidated. Because 14‐3‐3ε functions as a… read more here.
Keywords: phase; gastric cancer; atpr; filamin ... See more keywords
Jitterbug/Filamin and Myosin-II form a complex in tendon cells required to maintain epithelial shape and polarity during musculoskeletal system development
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.09.002
Abstract: During musculoskeletal system development, mechanical tension is generated between muscles and tendon-cells. This tension is required for muscle differentiation and is counterbalanced by tendon-cells avoiding tissue deformation. Both, Jbug/Filamin, an actin-meshwork organizing protein, and non-muscle… read more here.
Keywords: myosin; jbug filamin; tendon cells; filamin ... See more keywords
PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.016
Abstract: We show that amyloid-β1-42 (Aβ42) triggers a conformational change in the scaffolding protein filamin A (FLNA) to induce FLNA associations with α7-nicotinic acetylcholine receptor (α7nAChR) and toll-like receptor 4 (TLR4). These aberrant associations respectively enable… read more here.
Keywords: alzheimer disease; pti 125; filamin; conformation ... See more keywords
Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27896-z
Abstract: In epithelia, normal cells recognize and extrude out newly emerged transformed cells by competition. This process is the most fundamental epithelial defence against cancer, whose occasional failure promotes oncogenesis. However, little is known about what… read more here.
Keywords: mechanics; defence; epithelial defence; matrix ... See more keywords
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0141-0
Abstract: Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1α.… read more here.
Keywords: cytoskeleton; cell migration; filamin; ire1 ... See more keywords
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav8421
Abstract: The molecular chaperone HspB1 regulates the biomechanical extension of the heart muscle protein filamin C upon stress. Mechanical force–induced conformational changes in proteins underpin a variety of physiological functions, typified in muscle contractile machinery. Mutations… read more here.
Keywords: chaperone; filamin; hspb1 phosphorylation; interaction ... See more keywords
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm5029
Abstract: While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the… read more here.
Keywords: filamin; progressive supranuclear; tau aggregation; pathology ... See more keywords
Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059376
Abstract: ABSTRACT Filamins are large proteins with actin-binding properties. Mutations in FLNC, one of the three filamin genes in humans, have recently been implicated in dominant cardiomyopathies, but the underlying mechanisms are not well understood. Here,… read more here.
Keywords: crispr cas9; drosophila crispr; function; filamin ... See more keywords
The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260684
Abstract: Filamin A (FLNA) is an actin crosslinking protein that mediates mechanotransduction. External and internal mechanical forces, through the actin cytoskeleton, can induce conformational changes of the FLNA molecule to expose cryptic binding sites for its… read more here.
Keywords: interaction; filamin; g3bp1 interaction; formation ... See more keywords
Filamin protects myofibrils from contractile damage through changes in its mechanosensory region
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011101
Abstract: Filamins are mechanosensitive actin crosslinking proteins that organize the actin cytoskeleton in a variety of shapes and tissues. In muscles, filamin crosslinks actin filaments from opposing sarcomeres, the smallest contractile units of muscles. This happens… read more here.
Keywords: filamin; contractile damage; changes mechanosensory; region ... See more keywords
Blocking the Cleavage of Filamin A by Calpain Inhibitor Decreases Tumor Cell Growth.
Sign Up to like & getrecommendations! Published in 2018 at "Anticancer research"
DOI: 10.21873/anticanres.12447
Abstract: BACKGROUND/AIM Filamin A (FLNA) is the most abundant and widely expressed isoform of filamin in human tissues. It is cleaved by calpain at the hinge 1 and 2 domains, producing a 90-kDa carboxyl-terminal fragment (FLNACT).… read more here.
Keywords: calpain; filamin; cell growth; tumor cell ... See more keywords