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Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1583
Abstract: 4‐amino‐2‐trifluoromethyl‐phenyl retinate (ATPR) was able to induce the G0/G1 phase arrest in gastric cancer SGC‐7901 cells by downregulating 14‐3‐3ε. However, the mechanisms underlying this effect have not been fully elucidated. Because 14‐3‐3ε functions as a…
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Keywords:
phase;
gastric cancer;
atpr;
filamin ... See more keywords
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Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.09.002
Abstract: During musculoskeletal system development, mechanical tension is generated between muscles and tendon-cells. This tension is required for muscle differentiation and is counterbalanced by tendon-cells avoiding tissue deformation. Both, Jbug/Filamin, an actin-meshwork organizing protein, and non-muscle…
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Keywords:
myosin;
jbug filamin;
tendon cells;
filamin ... See more keywords
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Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.016
Abstract: We show that amyloid-β1-42 (Aβ42) triggers a conformational change in the scaffolding protein filamin A (FLNA) to induce FLNA associations with α7-nicotinic acetylcholine receptor (α7nAChR) and toll-like receptor 4 (TLR4). These aberrant associations respectively enable…
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Keywords:
alzheimer disease;
pti 125;
filamin;
conformation ... See more keywords
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Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27896-z
Abstract: In epithelia, normal cells recognize and extrude out newly emerged transformed cells by competition. This process is the most fundamental epithelial defence against cancer, whose occasional failure promotes oncogenesis. However, little is known about what…
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Keywords:
mechanics;
defence;
epithelial defence;
matrix ... See more keywords
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Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0141-0
Abstract: Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1α.…
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Keywords:
cytoskeleton;
cell migration;
filamin;
ire1 ... See more keywords
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Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav8421
Abstract: The molecular chaperone HspB1 regulates the biomechanical extension of the heart muscle protein filamin C upon stress. Mechanical force–induced conformational changes in proteins underpin a variety of physiological functions, typified in muscle contractile machinery. Mutations…
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Keywords:
chaperone;
filamin;
hspb1 phosphorylation;
interaction ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm5029
Abstract: While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the…
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Keywords:
filamin;
progressive supranuclear;
tau aggregation;
pathology ... See more keywords
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Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059376
Abstract: ABSTRACT Filamins are large proteins with actin-binding properties. Mutations in FLNC, one of the three filamin genes in humans, have recently been implicated in dominant cardiomyopathies, but the underlying mechanisms are not well understood. Here,…
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Keywords:
crispr cas9;
drosophila crispr;
function;
filamin ... See more keywords
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Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260684
Abstract: Filamin A (FLNA) is an actin crosslinking protein that mediates mechanotransduction. External and internal mechanical forces, through the actin cytoskeleton, can induce conformational changes of the FLNA molecule to expose cryptic binding sites for its…
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Keywords:
interaction;
filamin;
g3bp1 interaction;
formation ... See more keywords
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Published in 2018 at "Anticancer research"
DOI: 10.21873/anticanres.12447
Abstract: BACKGROUND/AIM Filamin A (FLNA) is the most abundant and widely expressed isoform of filamin in human tissues. It is cleaved by calpain at the hinge 1 and 2 domains, producing a 90-kDa carboxyl-terminal fragment (FLNACT).…
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Keywords:
calpain;
filamin;
cell growth;
tumor cell ... See more keywords