Impact of fill‐level in twin‐screw granulation on critical quality attributes of granules and tablets
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.02.010
Abstract: &NA; In a previous study a change of the fill‐level in the barrel exerted a huge influence on the twin‐screw granulation (TSG) process of a high drug loaded, simplified formulation. The present work investigated this… read more here.
Keywords: twin screw; fill level; screw granulation; level ... See more keywords
The impact of channel fill level on internal forces during continuous twin screw wet granulation
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DOI: 10.1016/j.ijpharm.2018.12.052
Abstract: ABSTRACT The forces experienced by the particles inside a twin screw granulator (TSG) are one of the most difficult parameters to measure quantitatively. However, it is possible to perform accurately this measurement through the use… read more here.
Keywords: granulation; twin screw; fill level; impact channel ... See more keywords
Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level
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DOI: 10.3390/pharmaceutics10020067
Abstract: This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets. Specific feed load (SFL) (powder… read more here.
Keywords: fill; size; barrel fill; fill level ... See more keywords