Silicone Oil Particles in Pre-Filled Syringes with Human Monoclonal Antibody Representative of Real-World Drug Products Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems.
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DOI: 10.1016/j.xphs.2019.09.026
Abstract: Silicone oil is a lubricant for pre-filled syringes (PFS), a common primary container for biotherapeutics. Silicone oil particles (SiOP) shed from PFS are a concern for patients due to their potential for increased immunogenicity and… read more here.
Keywords: filled syringes; immunogenicity; silicone oil; pre filled ... See more keywords