Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp8677
Abstract: Filopodia are actin-rich membrane protrusions essential for cell morphogenesis, motility, and cancer invasion. How cells control filopodia initiation on the plasma membrane remains elusive. We performed experiments in cellulo, in vitro and in silico to… read more here.
Keywords: membrane protrusions; irsp53; filopodia initiation; vasp ... See more keywords
VASP-mediated actin dynamics activate and recruit a filopodia myosin
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.68082
Abstract: Filopodia are thin, actin-based structures that cells use to interact with their environments. Filopodia initiation requires a suite of conserved proteins but the mechanism remains poorly understood. The actin polymerase VASP and a MyTH-FERM (MF)… read more here.
Keywords: actin; filopodia initiation; myosin; vasp ... See more keywords