Hierarchical joint analysis of marginal summary statistics—Part I: Multipopulation fine mapping and credible set construction
Sign Up to like & getrecommendations! Published in 2024 at "Genetic epidemiology"
DOI: 10.1002/gepi.22562
Abstract: Recent advancement in genome‐wide association studies (GWAS) comes from not only increasingly larger sample sizes but also the shift in focus towards underrepresented populations. Multipopulation GWAS increase power to detect novel risk variants and improve… read more here.
Keywords: multipopulation; analysis marginal; fine mapping; joint analysis ... See more keywords
Fine‐Mapping the Results From Genome‐Wide Association Studies of Primary Biliary Cholangitis Using SuSiE and h2‐D2
Sign Up to like & getrecommendations! Published in 2024 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22592
Abstract: The main goal of fine‐mapping is the identification of relevant genetic variants that have a causal effect on some trait of interest, such as the presence of a disease. From a statistical point of view,… read more here.
Keywords: susie rss; genome wide; primary biliary; biliary cholangitis ... See more keywords
Identification and fine mapping of a major locus controlling branching in Brassica napus
Sign Up to like & getrecommendations! Published in 2019 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-019-03506-x
Abstract: A candidate branching-controlling gene for qDBA09 was identified after delimiting a Brassica napus recessive locus within a 270-kb interval on chromosome A09. Although branching is an important trait associated with the adaptation and yield potential… read more here.
Keywords: brassica; fine mapping; analysis; brassica napus ... See more keywords
Fine mapping QSc.VR4, an effective and stable scald resistance locus in barley (Hordeum vulgare L.), to a 0.38-Mb region enriched with LRR-RLK and GLP genes
Sign Up to like & getrecommendations! Published in 2020 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-020-03599-9
Abstract: An effective and stable quantitative resistance locus, QSc.VR4, was fine mapped, characterized and physically anchored to the short arm of 4H, conferring adult plant resistance to the fungus Rhynchosporium commune in barley. Scald caused by… read more here.
Keywords: barley; effective stable; resistance; qsc vr4 ... See more keywords
Characterization and fine mapping of qPE12, a new locus controlling rice panicle exsertion
Sign Up to like & getrecommendations! Published in 2017 at "Euphytica"
DOI: 10.1007/s10681-017-2104-0
Abstract: Panicle exsertion is an important agronomic trait involved in pollination and hybrid rice seed production. The identification of genes controlling panicle exsertion will play a central role in hybrid rice breeding. C115, a chromosome segment… read more here.
Keywords: panicle exsertion; fine mapping; rice; panicle ... See more keywords
Fine mapping, candidate genes analysis, and characterization of a brown planthopper (Nilaparvata lugens Stål) resistance gene in the rice variety ARC5984
Sign Up to like & getrecommendations! Published in 2019 at "Euphytica"
DOI: 10.1007/s10681-019-2546-7
Abstract: The brown planthopper (Nilaparvata lugens Stål; BPH) is the most destructive rice pests worldwide. Identification and application of major resistance genes and cultivation of resistant varieties are the most efficient methods to control this insect.… read more here.
Keywords: rice; resistance gene; resistance; candidate genes ... See more keywords
Allele-Specific QTL Fine Mapping with PLASMA.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.12.011
Abstract: Although quantitative trait locus (QTL) associations have been identified for many molecular traits such as gene expression, it remains challenging to distinguish the causal nucleotide from nearby variants. In addition to traditional QTLs by association,… read more here.
Keywords: causal variants; qtl based; mapping; allele specific ... See more keywords
Fine mapping of a novel male-sterile mutant showing wrinkled-leaf in sesame by BSA-Seq technology
Sign Up to like & getrecommendations! Published in 2020 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.112862
Abstract: Abstract Genic male sterility (GMS) is a very important approach of heterosis exploitation in sesame (Sesamum indicum L.). Visible marker-trait linked to GMS is necessary since it can facilitate the breeding of new GMS lines… read more here.
Keywords: sesame; wrinkled leaf; showing wrinkled; male ... See more keywords
The flashfm approach for fine-mapping multiple quantitative traits.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26364-y
Abstract: Joint fine-mapping that leverages information between quantitative traits could improve accuracy and resolution over single-trait fine-mapping. Using summary statistics, flashfm (flexible and shared information fine-mapping) fine-maps signals for multiple traits, allowing for missing trait measurements… read more here.
Keywords: causal variants; mapping; single trait; fine mapping ... See more keywords
Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63842-z
Abstract: Head and neck squamous cell carcinoma (HNSCC) includes diverse cancers arising in the oral cavity, oropharynx, and larynx, with the main risk factors being environmental exposures such as tobacco, alcohol, and human papillomavirus (HPV) infection.… read more here.
Keywords: head neck; risk; cross ancestral; hnscc ... See more keywords
Genome-wide meta-analysis, fine-mapping, and integrative prioritization implicate new Alzheimer’s disease risk genes
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-020-00776-w
Abstract: Genome-wide association studies (GWAS) have discovered numerous genomic loci associated with Alzheimer’s disease (AD), yet the causal genes and variants remain incompletely identified. We performed an updated genome-wide AD meta-analysis, which identified 37 risk loci,… read more here.
Keywords: genome wide; risk; alzheimer disease; wide meta ... See more keywords