T cell asymmetry and metabolic crosstalk can fine-tune immunological synapses.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in immunology"
DOI: 10.1016/j.it.2021.06.007
Abstract: T cell asymmetry upon specific cell-cell interactions during mammalian immunological synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation and chaperones, such as the eukaryotic chaperonin containing TCP1 (CCT) for protein synthesis and… read more here.
Keywords: fine tune; cell asymmetry; asymmetry metabolic; crosstalk fine ... See more keywords
Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01976-x
Abstract: Vascular development is regulated by complicated signals and molecules in vertebrates. In this study, we characterized a novel function of carboxypeptidase N1 (Cpn1) in the vasculature. We show that cpn1 mRNA is expressed in developing… read more here.
Keywords: fine tune; controls vascular; cpn1; tune regulation ... See more keywords
Mastering an exhausting marathon: how CD8+ T cells fine‐tune metabolic fitness
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12517
Abstract: A recent study by Gabriel et al. provides novel insight into the metabolic pathways that contribute to T cell differentiation in chronic infection. The researchers discovered that metabolic plasticity and the function of exhausted T cells… read more here.
Keywords: mastering exhausting; fine tune; cells fine; exhausting marathon ... See more keywords
Probabilistic edge weights fine-tune Boolean network dynamics
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010536
Abstract: Biological systems are noisy by nature. This aspect is reflected in our experimental measurements and should be reflected in the models we build to better understand these systems. Noise can be especially consequential when trying… read more here.
Keywords: network; fine tune; edge; edge weights ... See more keywords
A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus
Sign Up to like & getrecommendations! Published in 2017 at "Aging and Disease"
DOI: 10.14336/ad.2016.1109
Abstract: Decline of transcription factor FoxN1, which predominantly regulates thymic epithelial cell (TEC) differentiation and homeostasis lifelong, is demonstrated to be casually related to age-related thymic involution. Whereas, a global role of microRNAs (miRNAs) has also… read more here.
Keywords: fine tune; age; aged thymus; expression ... See more keywords