An Integrated Phenotypic and Genotypic Approach Reveals a High‐Risk Subtype Association for EBF3 Missense Variants Affecting the Zinc Finger Domain
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26359
Abstract: Collier/Olf/EBF (COE) transcription factors have distinct expression patterns in the developing and mature nervous system. To date, a neurological disease association has been conclusively established for only the Early B‐cell Factor‐3 (EBF3) COE family member… read more here.
Keywords: missense variants; risk; finger domain; zinc finger ... See more keywords
The function of BED finger domain of Zbed3 in regulating lung cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28498
Abstract: Zbed3, a BED finger domain‐containing protein was found to promote cancer proliferation by regulating β‐catenin expression through interacting with Axin. But whether and how BED finger domain function in regulating cancer proliferation is unknown. We… read more here.
Keywords: bed finger; zbed3; proliferation; cancer ... See more keywords
Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01135
Abstract: Human exposure to arsenic in drinking water is known to be associated with the development of bladder, lung, kidney, and skin cancers. The molecular mechanisms underlying the carcinogenic effects of arsenic species remain incompletely understood.… read more here.
Keywords: dna interstrand; dna; ring finger; finger domain ... See more keywords
Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc00203h
Abstract: Cisplatin can directly bind to the RING finger domain of MDM2, leading to the zinc-release and protein unfolding. Consequently, cisplatin inhibits the MDM2-mediated ubiquitination, which is the molecular basis of p53 activation. This work provides… read more here.
Keywords: cisplatin binds; finger domain; ring finger; ubiquitination ... See more keywords
GATA zinc finger domain‐containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β‐thalassaemia through impaired formation of methyl‐binding domain protein 2 (MBD2)‐containing nucleosome remodelling and deacetylation (NuRD) complex
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17511
Abstract: Reactivation of fetal haemoglobin (HbF) expression is an effective way to treat β‐thalassaemia and sickle cell anaemia. In the present study, we identified a novel GATA zinc finger domain‐containing protein 2A (GATAD2A) mutation, which contributed… read more here.
Keywords: protein; fetal haemoglobin; domain containing; gata zinc ... See more keywords
Easy Expression and Purification of Fluorescent N-Terminal BCL11B CCHC Zinc Finger Domain
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247576
Abstract: Zinc finger proteins play pivotal roles in health and disease and exert critical functions in various cellular processes. A majority of zinc finger proteins bind DNA and act as transcription factors. B-cell lymphoma/leukemia 11B (BCL11B)… read more here.
Keywords: zinc finger; finger domain; terminal bcl11b; zinc ... See more keywords