Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors.
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DOI: 10.1021/acs.jmedchem.4c02516
Abstract: Pan-BD2 inhibitors have been shown to retain an antileukemia effect and display less dose-limiting toxicities than pan-BET inhibitors. However, it is necessary to consider the potential off-target toxicity associated with the inhibition of four BET… read more here.
Keywords: bd2; brd4 bd2; first brd4; selectivity ... See more keywords