First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.017
Abstract: The manuscript deals with the design, synthesis and biological evaluation of novel benzoxazinone-based and indole-based compounds as multifunctional neuroprotective agents. These compounds inhibit human adenosine kinase (hAK) and human glycogen synthase kinase 3 beta (hGSK-3β)… read more here.
Keywords: first dual; endowed antioxidant; dual gsk; gsk inhibitors ... See more keywords
The impact of medial-first dual plating for reduction of distal femoral fractures: a retrospective comparative cohort study
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-99271-7
Abstract: In dual-plate fixation of distal femoral fractures (DFF), reducing the relatively spared medial side first and using this metaphyseal-medial condylar segment as a template to reduce the lateral side may effectively facilitate reduction. This study… read more here.
Keywords: plate fixation; medial first; group; reduction ... See more keywords
First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04249h
Abstract: We report a new approach for the development of multitargeted therapeutics for Alzheimer's disease (AD) based on dual targeting of monomeric tau and biogenesis of microRNA-146a. Compound MG-1102 displayed a superior neuroprotective activity, in comparison… read more here.
Keywords: first dual; monomeric tau; multitargeted therapeutics; microrna 146a ... See more keywords