Assessment of Insulin Resistance Among Drug-Naive Patients With First-Episode Schizophrenia in the Context of Hormonal Stress Axis Activation
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2017.1983
Abstract: Before the introduction of antipsychotics, links between schizophrenia and abnormal glucose metabolism levels were found in the late 1800s as an increased prevalence of diabetes in families with a history of “insanity.”1 Furthermore, it is… read more here.
Keywords: among drug; schizophrenia; first episode; insulin resistance ... See more keywords
Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2018.3637
Abstract: Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain regions of a large population of human participants facilitates in vivo study of localized or diffusely altered brain metabolites in patients with first-episode… read more here.
Keywords: resonance spectroscopy; magnetic resonance; first episode; patients first ... See more keywords
Can neurocognition, brain neurotrophic factor, triglyceride, and total cholesterol predict suicidal ideation in first‐episode Han Chinese patients with schizophrenia?
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.3499
Abstract: Previous studies have suggested that the suicide rate of patients with schizophrenia is high. This study investigates factors influencing suicidal ideation in first‐episode schizophrenia patients, focusing on cognitive function, brain‐derived neurotrophic factor (BDNF), triglyceride (TG),… read more here.
Keywords: neurotrophic factor; first episode; brain; suicidal ideation ... See more keywords
A Synergistic Examination of Excitatory‐Inhibitory Balance in First‐Episode Schizophrenia Merging 7‐Tesla Magnetic Resonance Spectroscopic Imaging and Magnetoencephalography
Sign Up to like & getrecommendations! Published in 2025 at "Brain and Behavior"
DOI: 10.1002/brb3.70735
Abstract: Excitatory/inhibitory (E/I) imbalance is a proposed neural disruption in schizophrenia supported by magnetic resonance spectroscopic imaging (MRSI) evidence of altered gamma‐aminobutyric acid (GABA) and glutamate (Glu) levels. However, there exists a paucity of data linking… read more here.
Keywords: schizophrenia; excitatory inhibitory; first episode; spectroscopic imaging ... See more keywords
Psychotic symptoms in first-episode and drug naïve patients with major depressive disorder: Prevalence and related clinical factors.
Sign Up to like & getrecommendations! Published in 2020 at "Depression and anxiety"
DOI: 10.1002/da.23026
Abstract: BACKGROUND Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naïve (FEDN) MDD patients. This study… read more here.
Keywords: mdd patients; anxiety; first episode; prevalence ... See more keywords
Parahippocampal area three gray matter is reduced in first‐episode schizophrenia spectrum: Discovery and replication samples
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.25256
Abstract: Early course schizophrenia is associated with reduced gray matter. The specific structures affected first and how deficits impact symptoms and cognition remain unresolved. We used the Human Connectome Project multimodal parcellation (HCP‐MMP) to precisely identify… read more here.
Keywords: replication samples; schizophrenia; discovery replication; gray matter ... See more keywords
Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.25276
Abstract: Multi‐institutional brain imaging studies have emerged to resolve conflicting results among individual studies. However, adjusting multiple variables at the technical and cohort levels is challenging. Therefore, it is important to explore approaches that provide meaningful… read more here.
Keywords: first episode; multimodal mri; assessment first; mri assessment ... See more keywords
Morphological fingerprinting: Identifying patients with first‐episode schizophrenia using auto‐encoded morphological patterns
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26098
Abstract: Although a large number of case–control statistical and machine learning studies have been conducted to investigate structural brain changes in schizophrenia, how best to measure and characterize structural abnormalities for use in classification algorithms remains… read more here.
Keywords: encoded morphological; episode schizophrenia; first episode; auto encoded ... See more keywords
Heterogeneous brain dynamic functional connectivity patterns in first‐episode drug‐naive patients with major depressive disorder
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26266
Abstract: It remains challenging to identify depression accurately due to its biological heterogeneity. As people suffering from depression are associated with functional brain network alterations, we investigated subtypes of patients with first‐episode drug‐naive (FEDN) depression based… read more here.
Keywords: connectivity; network; first episode; episode drug ... See more keywords
Altered hippocampal centrality and dynamic anatomical covariance of intracortical microstructure in first episode psychosis
Sign Up to like & getrecommendations! Published in 2020 at "Hippocampus"
DOI: 10.1002/hipo.23215
Abstract: Hippocampal circuitry has been posited to be fundamental to positive symptoms in psychosis, but its contributions to other factors important for outcome remains unclear. We hypothesized that longitudinal changes in the hippocampal circuit and concomitant… read more here.
Keywords: first episode; dynamic anatomical; intracortical microstructure; episode psychosis ... See more keywords
Abnormal dynamic functional connectivity in first‐episode, drug‐naïve adolescents with major depressive disorder
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25047
Abstract: Previous neuroimaging studies have identified disrupted large‐scale functional brain networks in major depressive disorder (MDD); however, most of them focused on adult patients and were based on static functional connectivity (FC). Thus, we aimed to… read more here.
Keywords: state; first episode; major depressive; functional connectivity ... See more keywords