First-in-Human Real-Time MR-Guided Ventricular Ablation for Idiopathic Outflow Tract Premature Ventricular Complexes
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2025.3000
Abstract: Key Points Question Can real-time magnetic resonance (MR)–guided radiofrequency ablation be safely and effectively performed for ventricular arrhythmias without fluoroscopy? Findings In this first-in-human case from the VISABL-VT trial, a 73-year-old man underwent successful MR-guided… read more here.
Keywords: real time; ablation; first human; ventricular complexes ... See more keywords
First-in-human study of E7130 (a tumor microenvironment-ameliorating microtubule inhibitor) in patients with advanced solid tumors: Primary results of the dose-escalation part.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34788
Abstract: BACKGROUND E7130 is a novel anticancer agent created from a total synthetic study of norhalichondrin B. The authors report the E7130 dose-escalation part of a first-in-human study of patients with advanced solid tumors (NCT03444701). METHODS… read more here.
Keywords: dose escalation; group; escalation part; study ... See more keywords
First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Cancer"
DOI: 10.1002/cncr.35939
Abstract: Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme… read more here.
Keywords: solid tumors; first human; combination mogamulizumab; mogamulizumab patients ... See more keywords
First‐in‐Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742, a Dual Antagonist of Toll‐like Receptors 7 and 8, in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1176
Abstract: The first‐in‐human phase I study for E6742, a dual toll‐like receptor (TLR) 7 and TLR8 antagonist, has been conducted to assess the safety, tolerability, and pharmacokinetics of E6742 in healthy volunteers. In a single ascending… read more here.
Keywords: toll like; e6742 dual; safety; tolerability ... See more keywords
Confirmation of the Cardiac Safety of PGF2α Receptor Antagonist OBE022 in a First‐in‐Human Study in Healthy Subjects, Using Intensive ECG Assessments
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.447
Abstract: OBE022, a new orally active prostaglandin F2α receptor antagonist (OBE022) with myometrial selectivity is being developed to reduce uterine contractions during preterm labor. This first‐in‐human study evaluated the effect of OBE022 following multiple doses on… read more here.
Keywords: receptor antagonist; study; effect; human study ... See more keywords
First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation
Sign Up to like & getrecommendations! Published in 2024 at "Epilepsia Open"
DOI: 10.1002/epi4.13083
Abstract: Vagus nerve stimulation (VNS) is an effective treatment for people with drug‐resistant epilepsy. However, its mechanisms of action are poorly understood, including which nerve fibers are activated in humans during VNS in typical clinical settings… read more here.
Keywords: vagus nerve; human microelectrode; nerve stimulation; recordings vagus ... See more keywords
A FIRST‐IN‐HUMAN TRIAL OF THE NOVEL MULTI‐ACTION THERAPY TINOSTAMUSTINE (EDO‐S101) IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) HODGKIN LYMPHOMA (HL)
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.137_2630
Abstract: (95% CI: 5.0 days-1.9 months; Fig. 1). At a median follow up of 4.15 years 6 patients treated at target dose were still alive and treatment-free, whereas the 13 patients treated at lower dose levels… read more here.
Keywords: novel multi; trial novel; action therapy; first human ... See more keywords
First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12094
Abstract: Abstract Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti‐inflammatory effects. MSC‐EVs may serve as promising cell‐based therapeutics for the inner ear… read more here.
Keywords: extracellular vesicles; intracochlear application; msc evs; evs ... See more keywords
A Randomized First‐in‐Human Study With UB‐312, a UBITh® α‐Synuclein Peptide Vaccine
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29016
Abstract: α‐Synuclein (αSyn) is believed to play a central role in Parkinson's disease (PD) neuropathology and is considered a target for disease modification. UB‐312 is a synthetic αSyn peptide conjugated to a T helper peptide and… read more here.
Keywords: randomized first; study 312; peptide; 312 ubith ... See more keywords
First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04855-2
Abstract: This study assessed whether the newly developed PET radioligand [11C]PS13, which has shown excellent in vivo selectivity in previous animal studies, could be used to quantify constitutive levels of cyclooxygenase-1 (COX-1) in healthy human brain.… read more here.
Keywords: 11c ps13; human evaluation; pet radioligand; first human ... See more keywords
Intraluminal flexible sheath for the protection of low anastomosis after anterior resection: results from a First-In-Human trial on 15 patients
Sign Up to like & getrecommendations! Published in 2019 at "Surgical Endoscopy"
DOI: 10.1007/s00464-019-07279-8
Abstract: Defunctioning ostomy is commonly used to protect patients from anastomotic leakage complications after low anterior resection, but is fraught with its own deleterious effects. This first-in-human study examines the safety and preliminary efficacy of Colovac,… read more here.
Keywords: protection; anastomosis; first human; sheath ... See more keywords