The first Japanese case of central precocious puberty with a novel MKRN3 mutation
Sign Up to like & getrecommendations! Published in 2017 at "Human Genome Variation"
DOI: 10.1038/hgv.2017.17
Abstract: MKRN3, located on chromosome 15q11.2, encodes makorin ring-finger 3, which is an upstream suppressor of the hypothalamic-pituitary-gonadal axis. Mutation of this gene induces central precocious puberty (CPP). As MKRN3 is maternally imprinted, only the paternal… read more here.
Keywords: mkrn3; precocious puberty; first japanese; central precocious ... See more keywords
The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15506
Abstract: A lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which has poor outcomes. Here, we established 57 patient‐derived xenografts (PDXs)… read more here.
Keywords: lymphoblastic leukemia; biobank; patient derived; acute lymphoblastic ... See more keywords