Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan
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DOI: 10.1001/jamanetworkopen.2021.45515
Abstract: Key Points Question What are the comparative short-term and long-term outcomes associated with first-line chemotherapy regimens for patients with metastatic pancreatic cancer, and how do they compare with chemotherapy regimens recommended in Japanese guidelines? Findings… read more here.
Keywords: metastatic pancreatic; pancreatic cancer; first line; line chemotherapy ... See more keywords
Association Between Smoking History and Overall Survival in Patients Receiving Pembrolizumab for First-Line Treatment of Advanced Non–Small Cell Lung Cancer
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DOI: 10.1001/jamanetworkopen.2022.14046
Abstract: This cohort study compares the overall survival between patients who currently or formerly smoked with patients who never smoked and initiated pembrolizumab monotherapy as first-line treatment for advanced non–small lung cancer. read more here.
Keywords: first line; treatment advanced; overall survival; line treatment ... See more keywords
Comparison of FOLFIRINOX vs Gemcitabine Plus Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Ductal Adenocarcinoma
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DOI: 10.1001/jamanetworkopen.2022.16199
Abstract: Key Points Question Is there a difference in survival or toxic effects between the main first-line therapies used for metastatic pancreatic cancer? Findings In this comparative effectiveness study that included 1102 patients, FOLFIRINOX (combined leucovorin… read more here.
Keywords: gemcitabine plus; metastatic pancreatic; plus nab; first line ... See more keywords
Use of First-Line Immune Checkpoint Inhibitors and Association With Overall Survival Among Patients With Metastatic Melanoma in the Anti–PD-1 Era
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DOI: 10.1001/jamanetworkopen.2022.25459
Abstract: Key Points Question Following the US Food and Drug Administration’s approval of PD-1 immune checkpoint inhibitors (ICI) for metastatic melanoma, what were the utilization and overall survival associated with ICI in the first-line setting after… read more here.
Keywords: first line; overall survival; line; metastatic melanoma ... See more keywords
Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children
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DOI: 10.1001/jamanetworkopen.2023.6990
Abstract: This cohort study assesses the effectiveness of midazolam treatment in terminating pediatric seizures in the prehospital setting. read more here.
Keywords: midazolam prehospital; line therapy; midazolam; first line ... See more keywords
First-line Nivolumab Plus Ipilimumab vs Sunitinib for Metastatic Renal Cell Carcinoma: A Cost-effectiveness Analysis
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DOI: 10.1001/jamaoncol.2018.7086
Abstract: Importance Recently, new drugs have been approved for the first-line treatment of metastatic renal cell carcinoma (mRCC). Nivolumab plus ipilimumab significantly increases overall survival for intermediate- and poor-risk patients with mRCC. However, considering the high… read more here.
Keywords: first line; sunitinib; nivolumab plus; plus ipilimumab ... See more keywords
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
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DOI: 10.1001/jamasurg.2020.2286
Abstract: Importance Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (GA) are first-line chemotherapy regimens for pancreatic cancer. Their relative efficacy in the setting of localized disease is unknown. Objective To evaluate… read more here.
Keywords: response; line; first line; folfirinox ... See more keywords
Intranasal midazolam as first‐line inhospital treatment for status epilepticus: a pharmaco‐EEG cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50932
Abstract: We sought to evaluate the efficacy and tolerability of intranasal midazolam (in‐MDZ) as first‐line inhospital therapy in patients with status epilepticus (SE) during continuous EEG recording. read more here.
Keywords: first line; line inhospital; intranasal midazolam; status epilepticus ... See more keywords
Switches of tyrosine‐kinase inhibitors in chronic phase of chronic myeloid leukemia in real life
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DOI: 10.1002/ajh.25217
Abstract: To the Editor: Imatinib has transformed chronic myeloid leukemia (CML) prognosis with a survival rate of almost 83% at 10 years. The second and third generations of tyrosine-kinase inhibitors (TKIs) have enlarged the therapeutic possibilities.… read more here.
Keywords: first line; group; switch group; leukemia ... See more keywords
Mode of progression after first line treatment correlates with outcome of chronic lymphocytic leukemia (CLL)
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DOI: 10.1002/ajh.25561
Abstract: In CLL, progressive disease (PD) following remission after first line treatment can present with varying phenotypes. We hypothesized that the mode of PD correlates with clinical outcomes. Data from three phase III trials of the… read more here.
Keywords: cll; first line; group; line treatment ... See more keywords
Venous thromboembolism risk in cancer patients receiving first-line immune checkpoint inhibitor versus chemotherapy.
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DOI: 10.1002/ajh.26954
Abstract: It remains unclear if immune checkpoint inhibitor (ICI) therapy is associated with higher rate of venous thromboembolism (VTE) compared with cytotoxic chemotherapy (chemo) in patients with comparable cancer type, staging, and comorbidities. Using the national… read more here.
Keywords: first line; ici chemo; cancer; chemo ... See more keywords