Sustained Remission Without Corticosteroids Among Patients With Pemphigus Who Had Rituximab as First-Line Therapy: Follow-Up of the Ritux 3 Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.5679
Abstract: Importance The Ritux 3 trial demonstrated the short-term efficacy and safety of first-line treatment with rituximab compared with a standard corticosteroid regimen in pemphigus. No data on the long-term follow-up of patients who received rituximab… read more here.
Keywords: ritux trial; group; first line; line ... See more keywords
Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.45515
Abstract: Key Points Question What are the comparative short-term and long-term outcomes associated with first-line chemotherapy regimens for patients with metastatic pancreatic cancer, and how do they compare with chemotherapy regimens recommended in Japanese guidelines? Findings… read more here.
Keywords: metastatic pancreatic; pancreatic cancer; first line; line chemotherapy ... See more keywords
Association Between Smoking History and Overall Survival in Patients Receiving Pembrolizumab for First-Line Treatment of Advanced Non–Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.14046
Abstract: This cohort study compares the overall survival between patients who currently or formerly smoked with patients who never smoked and initiated pembrolizumab monotherapy as first-line treatment for advanced non–small lung cancer. read more here.
Keywords: first line; treatment advanced; overall survival; line treatment ... See more keywords
Comparison of FOLFIRINOX vs Gemcitabine Plus Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.16199
Abstract: Key Points Question Is there a difference in survival or toxic effects between the main first-line therapies used for metastatic pancreatic cancer? Findings In this comparative effectiveness study that included 1102 patients, FOLFIRINOX (combined leucovorin… read more here.
Keywords: gemcitabine plus; metastatic pancreatic; plus nab; first line ... See more keywords
Use of First-Line Immune Checkpoint Inhibitors and Association With Overall Survival Among Patients With Metastatic Melanoma in the Anti–PD-1 Era
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.25459
Abstract: Key Points Question Following the US Food and Drug Administration’s approval of PD-1 immune checkpoint inhibitors (ICI) for metastatic melanoma, what were the utilization and overall survival associated with ICI in the first-line setting after… read more here.
Keywords: first line; overall survival; line; metastatic melanoma ... See more keywords
Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.6990
Abstract: This cohort study assesses the effectiveness of midazolam treatment in terminating pediatric seizures in the prehospital setting. read more here.
Keywords: midazolam prehospital; line therapy; midazolam; first line ... See more keywords
Therapy Attrition and Lessons for Future Approaches to Treatment of Advanced Urothelial Cancer.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2024.9426
Abstract: Metastatic or advanced urothelial cancer (aUC) is an aggressive disease, and many patients with this malignant neoplasm do not survive past their first line of therapy. The study by Thomas et al 1 is important… read more here.
Keywords: oncology; treatment; urothelial cancer; first line ... See more keywords
PARP Inhibitor Maintenance After First-Line Chemotherapy in Advanced-Stage Epithelial Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.41648
Abstract: This systematic review and meta-analysis investigates the association of first-line poly(adenosine diphosphate-ribose) polymerase inhibitor (PARP inhibitor) maintenance therapy with efficacy and safety outcomes among patients with advanced-stage epithelial ovarian cancer. read more here.
Keywords: parp inhibitor; stage epithelial; first line; inhibitor ... See more keywords
First-line Nivolumab Plus Ipilimumab vs Sunitinib for Metastatic Renal Cell Carcinoma: A Cost-effectiveness Analysis
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.7086
Abstract: Importance Recently, new drugs have been approved for the first-line treatment of metastatic renal cell carcinoma (mRCC). Nivolumab plus ipilimumab significantly increases overall survival for intermediate- and poor-risk patients with mRCC. However, considering the high… read more here.
Keywords: first line; sunitinib; nivolumab plus; plus ipilimumab ... See more keywords
Nivolumab + Ipilimumab as Immunotherapeutic Boost in Metastatic Urothelial Carcinoma: A Nonrandomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.0938
Abstract: Importance Studies with nivolumab, an approved therapy for metastatic urothelial carcinoma (mUC) after platinum-based chemotherapy, demonstrate improved outcomes with added high-dose ipilimumab. Objective To assess efficacy and safety of a tailored approach using nivolumab + ipilimumab as… read more here.
Keywords: cohort; line cohort; second third; first line ... See more keywords
Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA surgery"
DOI: 10.1001/jamasurg.2020.2286
Abstract: Importance Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (GA) are first-line chemotherapy regimens for pancreatic cancer. Their relative efficacy in the setting of localized disease is unknown. Objective To evaluate… read more here.
Keywords: response; line; first line; folfirinox ... See more keywords