First in man study of a new semi‐open cell design Zephyr cobalt–chromium stent in large vessels and conduits
Sign Up to like & getrecommendations! Published in 2020 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.28737
Abstract: We present a first‐in‐man clinical use of a new hybrid design stent in stenosed large vessels. Its unique C and S polylinks prevent foreshortening without compromising its strength. Its thin profile permits use of smaller… read more here.
Keywords: large vessels; first man; man study; stent ... See more keywords
The first‐in‐man randomized trial of a beta3 adrenoceptor agonist in chronic heart failure: the BEAT‐HF trial
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.714
Abstract: The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and β2 ARs. Stimulation of β3 ARs may reduce cardiomyocyte Na+ overload and reduce oxidative stress in… read more here.
Keywords: agonist; trial; first man; heart failure ... See more keywords
A Novel Implant for the Prophylactic Treatment of Impending Pathological Fractures of the Proximal Femur: Results from a Prospective, First-in-Man Study
Sign Up to like & getrecommendations! Published in 2017 at "CardioVascular and Interventional Radiology"
DOI: 10.1007/s00270-017-1613-5
Abstract: ObjectivesTo prospectively evaluate a novel implant, Y-STRUT® (Hyprevention, Pessac, France), designed to provide prophylactic reinforcement of the proximal femur in metastatic patients.MethodsTen patients presenting lytic lesions of the proximal femur were to be treated. The… read more here.
Keywords: treatment; proximal femur; man study; first man ... See more keywords
CORONARY SINUS REDUCER™ RETAINS PATENCY AND EFFICACY AT TWELVE YEARS: A FIRST IN MAN PROSPECTIVE CARDIAC CT ANGIOGRAPHY OUTCOME STUDY
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)30802-7
Abstract: Coronary Sinus (CS) Reducer™ was designed to establish a permanent controlled narrowing of the coronary sinus for patients with no-options refractory angina. A first-in-man clinical study provided an indication for safety and feasibility of the… read more here.
Keywords: first man; coronary sinus; sinus; sinus reducer ... See more keywords
4069From first in man transcatheter aortic valve implantation, a 15-year experience
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.0093
Abstract: Since the first-in-man transcatheter aortic valve implantation (TAVI) performed in 2002, the number of procedures has dramatically increased. However, long-term data regarding outcome and valve durability remain poor. We aimed to evaluate the evolution of… read more here.
Keywords: first man; valve; man transcatheter; valve durability ... See more keywords
First-in-Man Use of a Modified Controller to Resolve HVAD Failure-to-Restart.
Sign Up to like & getrecommendations! Published in 2023 at "ASAIO journal"
DOI: 10.1097/mat.0000000000001911
Abstract: We report a case of Medtronic HeartWare ventricular assist device (HVAD) pump failure-to-restart. Despite HVAD withdrawal from the market in June 2021, up to 4,000 patients remain on HVAD support worldwide, and many are at… read more here.
Keywords: failure restart; controller; first man; man use ... See more keywords
A randomized, double‐blind, placebo‐controlled, dose‐escalation first‐in‐man study (phase 0) to assess the safety and efficacy of topical cytosolic phospholipase A2 inhibitor, AVX001, in patients with mild to moderate plaque psoriasis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14128
Abstract: Cytosolic phospholipase A2 (cPLA2α) is an enzyme suggested as a therapeutic target in inflammatory skin diseases. AVX001, a cPLA2α inhibitor, was investigated in a randomized, double‐blind, placebo‐controlled, split‐design, first‐in‐man study in patients with mild to… read more here.
Keywords: randomized double; cytosolic phospholipase; placebo controlled; first man ... See more keywords
A first-in-man phase I/II study of OBI-3424, an AKR1C3-selective bis-alkylating agent prodrug, in subjects with advanced cancer, including hepatocellular carcinoma (HCC) and castrate-resistant prostate cancer (CRPC).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.tps3658
Abstract: TPS3658Background: Aldo-keto reductase family 1 member C3 (AKR1C3) modulates cellular differentiation and proliferation through indirect regulation of ligand access to hormone and nuclear receptor ... read more here.
Keywords: obi 3424; man phase; first man; study obi ... See more keywords
An arginase1- and PD-L1-derived peptide-based vaccine for myeloproliferative neoplasms: A first-in-man clinical trial
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1117466
Abstract: Introduction Arginase-1 (ARG1) and Programed death ligand-1 (PD-L1) play a vital role in immunosuppression in myeloproliferative neoplasms (MPNs) and directly inhibit T-cell activation and proliferation. We previously identified spontaneous T-cell responses towards PD-L1 and ARG1… read more here.
Keywords: derived peptide; first man; vaccine; arg1 derived ... See more keywords
First-in-man use of an Indian-made balloon-expandable covered Zephyr stent and intermediate-term follow-up
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Pediatric Cardiology"
DOI: 10.4103/apc.apc_122_22
Abstract: Covered stent is used in large-vessel angioplasty in anticipation of vessel wall injury. Apart from aortic coarctation, they are also used in dysfunctional right ventricular outflow conduits and find a recent role in transcatheter sinus… read more here.
Keywords: indian made; balloon expandable; man use; first man ... See more keywords