Starting dose selection and dose escalation for oncology small molecule first-in-patient trials: learnings from a survey of FDA-approved drugs
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DOI: 10.1007/s00280-020-04202-0
Abstract: The ideal starting dose for an oncology first-in-patient (FIP) trial should be low enough to be safe but not too far removed from therapeutically relevant doses. A low starting dose combined with small dose increments… read more here.
Keywords: first patient; dose escalation; starting dose; small molecule ... See more keywords
Ecthyma gangrenosum caused by Staphylococcus aureus in hematological malignancies: Case reports and literature review
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DOI: 10.1097/md.0000000000030070
Abstract: Rationale: Ecthyma gangrenosum (EG) is a potentially life-threatening, systemic infection generally caused by Pseudomonas aeruginosa. Data on EG caused by Staphylococcus aureus in patients with hematological malignancies are scarce. The present case report aimed to… read more here.
Keywords: first patient; staphylococcus aureus; hematological malignancies; ecthyma gangrenosum ... See more keywords
The First Patient Report of Tongue Abscess Among Iraqi Population.
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DOI: 10.1097/scs.0000000000004257
Abstract: Tongue abscess is a serious clinical entity which scarcely affects the tongue. It should be treated urgently to prevent airway obstruction or dissemination of infection to a more deep or distant area of the body.… read more here.
Keywords: first patient; patient report; tongue abscess; report tongue ... See more keywords
My First Patient With Alzheimer's
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DOI: 10.1212/wnl.0000000000201087
Abstract: When I forget where I left the keysI think of him—his silver hair,thick hands worthy of Rome's colosseum,back straight despite the weight of his history,gun-metal blue eyes refusing to cloud over.His crumbling memory. read more here.
Keywords: first patient; neurology; patient alzheimer;
The first patient treated with a triple combination therapy after recurrent ischemic stroke
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DOI: 10.25122/jml-2019-1006
Abstract: This case report presents the evolution of a patient with recurrent ischemic stroke, in the context of treatment with multimodal agent cerebrolysin, as an add-on to neurological rehabilitation and tDCS therapy. The patient was evaluated… read more here.
Keywords: combination; first patient; ischemic stroke; recurrent ischemic ... See more keywords
Virus Isolation from the First Patient with SARS-CoV-2 in Korea
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DOI: 10.3346/jkms.2020.35.e84
Abstract: Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We… read more here.
Keywords: first patient; patient sars; cov korea; isolation first ... See more keywords